Cantrell, D.A., Robins, R.A., Brooks, C.G. and Baldwin, R.W.
Cancer Research Laboratories, University of Nottingham, U.K.

Immunology, 45: 97-104, 1982.
 

The fluorescence-activated cell sorter and a rosette-depletion technique were used to separate spleen lymphocytes and BCG-activated lymphocytes into subpopulations with and without the antigens defined by W3/13, W3/23 and OX8 monoclonal antibodies. The resultant populations were then tested for natural killer (NK) activity in a quantifiable 6 hr 51Cr release assay. The data establish that natural killer cells are heterogeneous with respect to their surface antigen expression and that subpopulations of NK cells express the OX8 and W3/13 defined antigens. However, NK cells do not express the antigen defined by W3/24 monoclonal antibody.