| Figure
6. All Qa1
receptors on adult NK cells and on NK cells that develop in vitro from early
thymic progenitors contain NKG2 molecules |
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A. Preincubated with
medium |
B. Preincubated with
anti-NKG2 |
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| Qa1R |
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Qa1R |
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| Developing
NK cells in IL2 containing secondary cultures were incubated with medium or |
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| anti-NKG2
mAb, then with Qa1 tetramers |
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| Conclusions |
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| 1. Anti-NKG2 mAb completely blocks the
binding of Qa1 tetramers to developing NK cells |
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| 2. The Qa1 receptors on developing NK cells
contain NKG2 molecules and, based on other studies |
| showing
that NKG2 is only expressed in association with CD94, are presumably
CD94/NKG2 |
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| heterodimers |
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| 3. NKG2-containing receptors are the only
receptors for Qa1 on developing NK cells |
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| 4. Similar experiments [data not shown]
demonstrate that NKG2-containing receptors are the only |
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| receptors
for Qa1 on adult NK cells |
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