Figure 8. Individual thymic progenitors can develop into populations of NK
cells that show highly diverse expression of CD94/NKG2 receptors and Ly49
molecules
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| CD94 |
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CD94 |
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4D12 |
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4D12 |
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above plots show the expression of CD94 and Ly49 molecules on the cells
present within |
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clones of NK cells that developed from single thymic progenitor cells |
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| Conclusions |
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| 1. Individual thymic progenitor cells can
give rise to populations of NK cells that have a similar |
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of diversity to NK cells that develop in bulk cultures |
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| 2. The fact that each clone is different in
composition indicates that the stochastic events that |
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the generation of diversity occur relatively infrequently during the
development of a clone |
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| 3. The results show unambiguously that CD94hi and CD94lo NK cells are derived
from a common |
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