Research / Projects
This page details the current and past funded research projects for
which I am an investigator.
Current projects
- A new frontier in design: the simulation of open engineered
biological systems: This is an EPSRC Frontier
Engineering award. Also see the Newcastle University press
release, and the grant details on GoW. Further details regarding opportunities for working on this project will appear here
shortly.
- Functional dissection of the genetic interaction network that
affects growth of cells with telomere defects: implications for health
and disease: This is an MRC
funded project to map the network of genetic interactions between
genes known to be be important for telomere integrity. We have a private wiki for collaborative working.
- The telomere cap in budding yeast: This is a Wellcome Trust funded project to develop high throughput
robotic screening methods and data analysis pipelines for uncovering
genetic interactions relevant to telomere integrity. We have a private wiki for collaborative working.
- Quantitative Fitness Analysis to understand the
Schizosaccharomyces pombe telomere cap: This is a Cancer
Research UK funded project to adapt the high throughput robotic
genetic methods we have pioneered in budding yeast to work with
fission yeast.
Recent projects
- Heterogeneity: Integrative modelling of stochasticity,
noise, heterogeneity and measurement error in the study of model
biological systems (1/9/08-31/8/11). This was my BBSRC Research Development
Fellowship (grant number BB/F023545/1), which involved a
combination of statistical modelling and experimental lab work. I have
a private
wiki for collaborative working. Additional information regarding
this Fellowship is available from my research interests page.
- ONDEX: from data to knowledge / the ONDEX system for
integrating Life Sciences data sources. This project was funded by the
BBSRC SABR initiative. There is a private wiki for
collaborative working, and another wiki for the
Newcastle component.
- CISBAN: the Centre
for Integrated Systems Biology of Ageing and Nutrition. This was a BBSRC funded centre for Integrative
Systems Biology. The centre continues to exist as a Newcastle
University Research Centre. In addition to the main web site, there is a private wiki for collaborative
working. I lead the CISBAN working group on biomathematical
and statistical modelling within the in
silico programme.
- CaliBayes:
integration of post-genomic data resources through Bayesian
calibration of biological simulators. This was funded by BBSRC's
Bioinformatics and e-Science programme. Although direct funding is now finished, the project
continues as a key technological component of CISBAN.
- ComparaGRID:
enabling technologies for comparative genomics. This project was funded
by the BBSRC Bioinformatics and e-Science programme. In addition to
the main site, there are a variety of internal sites for collaborative
working, most of which are linked to from my private wiki
page for the project.
- NEReSC: the
North-East Regional e-Science Centre. This is an EPSRC-funded project. I was involved
in a grant extending the life of the originally funded centre.
- BASIS: Biology of
Ageing e-Science Integration and Simulation system. This
BBSRC Bioinformatics and e-Science grant was designated a UK GRID
Pilot Project. Although direct funding is now finished, the project
continues as a key technological component of CISBAN.
- GeneNets:
Bayesian inference for stochastic kinetic genetic regulatory
networks. This project was funded by the BBSRC Bioinformatics
initiative, and marked the start of my research in this area.
- Parallel
Bayesian computation: this was an equipment grant from the Royal Society which allowed me to purchase an 8-CPU linux
Beowulf cluster for experimenting with parallel algorithms for
Bayesian computation.
