Research / Projects
This page details the current and past funded research projects for
which I am an investigator.
Current projects
- The telomere cap in budding yeast: This is a Wellcome Trust funded project to develop high throughput
robotic screening methods and data analysis pipelines for uncovering
genetic interactions relevant to telomere integrity. We have a private wiki for collaborative working.
- Quantitative Fitness Analysis to understand the
Schizosaccharomyces pombe telomere cap: This is a Cancer
Research UK funded project to adapt the high throughput robotic
genetic methods we have pioneered in budding yeast to work with
fission yeast.
Recent projects
- Heterogeneity: Integrative modelling of stochasticity,
noise, heterogeneity and measurement error in the study of model
biological systems (1/9/08-31/8/11). This was my BBSRC Research Development
Fellowship (grant number BB/F023545/1), which involved a
combination of statistical modelling and experimental lab work. I have
a private
wiki for collaborative working. Additional information regarding
this Fellowship is available from my research interests page.
- ONDEX: from data to knowledge / the ONDEX system for
integrating Life Sciences data sources. This project was funded by the
BBSRC SABR initiative. There is a private wiki for
collaborative working, and another wiki for the
Newcastle component.
- CISBAN: the Centre
for Integrated Systems Biology of Ageing and Nutrition. This was a BBSRC funded centre for Integrative
Systems Biology. The centre continues to exist as a Newcastle
University Research Centre. In addition to the main web site, there is a private wiki for collaborative
working. I lead the CISBAN working group on biomathematical
and statistical modelling within the in
silico programme.
- CaliBayes:
integration of post-genomic data resources through Bayesian
calibration of biological simulators. This was funded by BBSRC's
Bioinformatics and e-Science programme. Although direct funding is now finished, the project
continues as a key technological component of CISBAN.
- ComparaGRID:
enabling technologies for comparative genomics. This project was funded
by the BBSRC Bioinformatics and e-Science programme. In addition to
the main site, there are a variety of internal sites for collaborative
working, most of which are linked to from my private wiki
page for the project.
- NEReSC: the
North-East Regional e-Science Centre. This is an EPSRC-funded project. I was involved
in a grant extending the life of the originally funded centre.
- BASIS: Biology of
Ageing e-Science Integration and Simulation system. This
BBSRC Bioinformatics and e-Science grant was designated a UK GRID
Pilot Project. Although direct funding is now finished, the project
continues as a key technological component of CISBAN.
- GeneNets:
Bayesian inference for stochastic kinetic genetic regulatory
networks. This project was funded by the BBSRC Bioinformatics
initiative, and marked the start of my research in this area.
- Parallel
Bayesian computation: this was an equipment grant from the Royal Society which allowed me to purchase an 8-CPU linux
Beowulf cluster for experimenting with parallel algorithms for
Bayesian computation.
