Selected Publications
12. Willmore, E., Elliott, S.L.,
Mainou-Fowler, T., Summerfield, G.P., Jackson, G.H., O'Neill, F., Lowe,
C., Carter, A., Harris, R., Pettitt, A.R.,Cano-Soumillac, C.,Griffin,
R. J., Cowell, I. G., Austin, C. A. and Durkacz, B. W. (2008).
DNA-dependent protein kinase is a therapeutic target and an indicator
of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer
Res 14, 3984-3992.
11. Toyoda,
E., Kagaya, S., Cowell, I.G., Kurosawa, A., Kamoshita, K., Nishikawa,
K., Iiizumi, S., Koyama, H., Austin, C.A., and Adachi, N. (2008).
NK314, a topoisomerase II inhibitor that specifically targets the alpha
isoform. J Biol Chem 283, 23711-23720.
10. Cowell, I.G., Sunter, N.J., Singh,
P.B., Austin, C.A., Durkacz, B.W., and Tilby, M.J. (2007). gammaH2AX
foci form preferentially in euchromatin after Ionising-radiation. PLoS
ONE 2, e1057.
9. Leontiou, C., Watters, G.P., Gilroy,
K.L., Heslop, P., Cowell, I.G., Craig, K., Lightowlers, R.N., Lakey,
J.H., and Austin, C.A. (2007). Differential selection of acridine
resistance mutations in human DNA topoisomerase IIbeta is dependent on
the acridine structure. Mol Pharmacol 71, 1006-1014.
8. Zhao, Y., Thomas, H.D., Batey, M.A.,
Cowell, I.G., Richardson, C.J., Griffin, R.J., Calvert, H.A., Newell,
D.R., Smith, G.C.M., and Curtin, N.J. (2006). Preclinical evaluation of
a potent novel DNA-dependent protein kinase (DNA-PK) inhibitor, NU7441.
Cancer Res 66, 5354-5362.
7. Cowell, I.G., Durkacz, B.W., and Tilby,
M.J. (2005). Sensitization of breast carcinoma cells to ionizing
radiation by small molecule inhibitors of DNA-dependent protein kinase
and ataxia telangiectsia mutated. Biochem Pharmacol 71, 13-20.
6. Brown, J.P., Singh, P.B., and Cowell,
I.G. (2003). Composite cis-acting epigenetic switches in eukaryotes:
lessons from Drosophila Fab-7 for the Igf2-H19 imprinted domain.
Genetica 117, 199-207.
5. Cowell, I.G., Aucott, R., Mahadevaiah,
S.K., Burgoyne, P.S., Huskisson, N., Bongiorni, S., Prantera, G.,
Fanti, L., Pimpinelli, S., Wu, R., et al. (2002). Heterochromatin, HP1
and methylation at lysine 9 of histone H3 in animals. Chromosoma 111,
22-36.
4. Filesi, I., Cardinale, A., van Der,
S.S., Cowell, I.G., Singh, P.B., and Biocca, S. (2002). Loss of
Heterochromatin Protein 1 (HP1) chromodomain function in mammalian
cells by intracellular antibodies causes cell death. J. Cell Sci. 115,
1803-1813.
3.
Scholzen, T., Endl, E., Wohlenberg, C., van Der, S.S., Cowell, I.G.,
Gerdes, J., and Singh, P.B. (2002). The Ki-67 protein interacts with
members of the heterochromatin protein 1 (HP1) family: a potential role
in the regulation of higher-order chromatin structure. J. Pathol. 196,
135-144.
2.Wang, G., Ma, A., Chow, C.M., Horsley,
D., Brown, N.R., Cowell, I.G., and Singh, P.B. (2000). Conservation of
heterochromatin protein 1 function. Mol Cell Biol 20,
6970-6983.