Journal Publications

Simon Doherty, Julian G. Knight, John P. McGrady, Alexandra M. Ferguson, Nicholas A. B. Ward, Ross W. Harrington, and William Clegg, Adv. Synth. Catal., 2010, 352, 201.

 ortho,ortho’-Substitution of the phosphinoalkyne-derived aryl ring in KITPHOS (11-di-cyclohexylphosphino-12-phenyl-9,10-ethenoanthracene)monophosphines enhances the performance of this class of ligand in palladium-catalyzed Suzuki–Miyaura cross-couplings and Buchwald–Hartwig aminations, compared with their unsubstituted and mono-substituted counterparts. An alternative complementary synthesis of KITPHOS monophosphines has been developed and two new members of this family, 2,6-Me2-KITPHOS [11-dicyclohexylphosphino-12-(2,6-dimethylphenyl)-9,10-ethenoanthracene] and 2,6-(MeO)2-KITPHOS [11-dicyclohexylphosphino-12-(2,6-dimethoxyphenyl)- 9,10-ethenoanthracene], have been prepared; palladium complexes of both are highly efficient catalysts for CC and CN bond formation with a range of electron-rich and electron-poor aromatic chlorides as well as heteroaryl chlorides.