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Dr. Jeremy Brown

Senior Lecturer

RNA Biology Group and
Institute for Cell and Molecular Biosciences
The Medical School, Newcastle University

Newcastle upon Tyne, NE2 4HH

E-mail: jeremy.brown@ncl.ac.uk
Phone: (+44) 0191-222-7470/7877
FAX: (+44) 0191-222-7424

Publications - Links (NUFC, Cacti and more) - Lab. Members

Cellular function requires that activities are harnessed and controlled, often within large molecular machines. Amongst these, a number of key complexes comprise non-coding RNA and protein. These ribonucleoproteins ("RNPs") play key roles in many essential cellular processes, including maintenance of telomeres, dosage compensation, transcription, pre-mRNA splicing, translation and protein targeting. The RNA components of RNPs while having key structural roles in the complexes, are also typically involved in substrate recognition and/or catalysis. In eukaryotic cells these RNAs may be generated by any one of the three RNA polymerases (I, II or III). Work in our laboratory is focussed on the biogenesis and function of RNPs. Within this broader area we have several projects:

Protein targeting to the endoplasmic reticulum by the cytosolic ribonucleoprotein signal recognition particle (SRP) that catalyses this.

Biogenesis of RNPs, and particularly those containing an RNA transcribed by RNA polymerase III. Part of this work is collaborative with Dr. Nick Watkins, also here at Newcastle University.

Translational recoding driven by the 2A peptide of Foot-and-Mouth disease virus and various other positive strand RNA viruses. This project is collaborative with Dr. Martin Ryan at the University of St. Andrews UK and Prof. Matthew Sachs at Texas A&M University, College Station, Texas USA.

Work in our laboratory is currently funded by the BBSRC

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