(R)-sub + (R)-der ------> (R,R)-sub-der
(A)
+ (S)-der
(R,S)-sub-der (B)
Now consider the reaction between a racemic substrate [(R)-sub / (S)-sub] and an enantiomerically pure derivatizing agent [(R)-der]
(R)-sub + (R)-der ------> (R,R)-sub-der (C)
(S)-sub
(S,R)-sub-der (D)
Reaction A is identical to reaction C. The only difference between these
two situations in in reactions B and D, for which both the starting materials
and products are enantiomeric. Reactions B and D will have identical energy
profiles, since the starting materials are enantiomeric (and so of equal
energy), the products are enantiomeric (and so of equal energy), and any
point along the reaction pathway of reaction B will be enantiomeric with
the corresponding point of reaction D. Thus, if any kinetic resolution
occured in reaction B, an identical kinetic resolution would be observed
in reaction D.
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