Enantiomers have opposite configurations at every stereocentre.
Replacement in turn of each of a pair of heterotopic groups by a different
ligand generates a new stereocentre the configuration of which will be
R in one case and S in the other. However, if another stereocentre
is present elsewhere in the molecule, the configuration (R or S)
of this stereocentre is unchanged by the above process. Thus the two species
formed in the process discussed above will be diastereomers since they
will have the same configuration at one stereocentre and the opposite configuration
at the other. Hence the two heterotopic groups will be diastereotopic.
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