Image now available on FigshareIntra-cellular protein trafficking and signalling: I have worked on signalling systems and protein trafficking for a number of years. In particular I am interested in the regulation of the sorting and trafficking of the glucose transporter GLUT4 and how diabetes causes a dysfunction in the insulin-signalling pathway and therefore a failure of GLUT4 to translocate to the plasma-membrane. My interest in trafficking and signalling also drive, and provide the data for, my other research interests.
I am currently based in at Newcastle University Medicine Malaysia (NUMed) where I am the Degree Programme Director (DPD) for the Biomedical Sciences (BMS) degree.
Previous to NUMed I worked at the School of Biomedical Sciences for 14 years where I taught on twelve degree programmes: Biological Sciences, BSc Deferred Choice; Biochemistry, BSc; Biochemistry with Immunology, BSc; Biomedical Sciences, BSc' Biomedical Sciences with Management, BSc; Biotechnology, BSc; Biotechnology, BSc with industrial placement year; Biomedical Genetics, BSc; Medical Microbiology and Immunology, BSc; Pharmacology, BSc; Physiological Sciences, BSc; and MSci Biomedical Sciences (Integrated Masters) (4 year programme). I was also module leader for 5 modules taught in the School.
The subject areas I covered, and still teach at NUMed, are basic laboratory skills (biochemistry), academic skills, bioinformatics, cell signalling (insulin signalling, and G-protein coupled receptors), proteomics, and protein trafficking.
My research interests are in signal transduction, protein trafficking, proteomics and bioinformatics. In my previous positions I have examined intracellular signalling in the Müller cells of the retina, the phosphorylation of the alpha subunit of the heterotrimeric G-protein Gi-2 in hepatocyte, and the trafficking of the insulin-responsive vesicles that contain the glucose transporter GLUT4.
Proteomics: Previous, and current, projects have included a large element of proteomics. The analysis of the protein components of the GLUT4 vesicles was a proteomics project, as was my work on the characterisation of the protein phosphorylation sites of alpha Gi2. I was also a co-founder of the proteomics facility at Newcastle University.
Bioinformatics: Throughout my research career I have used available computing facilities/systems to help with the analysis and design of experiments. Over the years I have developed a range of bioinformatics and computing skills including programming in php, C and objective-C as well as basic system administration and MySQL skills. I also helped establish the Bioinformatics Support Unit at Newcastle University.
On-going collaborations: I am currently involved in a number of on-going collaborations in bioinformatics and proteomics.