Effector Link
[EspZ] [Map] [Tir] [EspH] [EspG] [EspF]

EspB - EPEC secreted protein B

EspB Protein Sequence of EPEC strain E2348/69
pubmed

Back to EPEC Lab Page

MNTIDNNNAAIAVNSVLSSTTDSTSSTTTSTSSISSSLLTDGRVDISKLLLEVQKLLREMVTTLQDYLQK QLAQSYDIQKAVFESQNKAIDEKKAGATAALIGGAISSVLGILGSFAAINSATKGASDVAQQAASTSA KSIGTVSEASTKALAKASEGIADAADDAAGAMQQTIATAAKAASRTSGITDDVATSAQKASQVAEEAA DAAQELAQKAGLLSRFTAAAGRISGSTPFIVVTSLAEGTKTLPTTISESVKSNHDINEQRAKSVENLQAS NLDTYKQDVRRAQDDISSRLRDMTTTARDLTDLINRMGQAARLAG

EspB Publications

Homologues

EspB Features

Secondary Structure.pdf

Colour Alignment

Phylogenetic Tree

REPORTED FUNCTIONS

Microvilli Effacement, Anti-phagocytosis, Alters actin cytoskeleton, A translocator - forms pores in plasma membrane, essential for effector translocation

PROVEN BINDING PARTNERS

 

SUBCELLULAR LOCATIONS

Cytoplasm, Plasma Membrane

PHYSICO-CHEMICAL

321 amino acids, 33.1 kDa, pI 5.24 

DISCOVERED BY

James Kaper’s Lab (Donnenberg et al, 1993) - formely eaeB

FUNCTIONAL MOTIFS

 

DNA Sequence of the espB gene of EPEC strain E2348/69 

ATGAATACTATCGATAATAACAATGCGGCAATCGCAGTTAATTCTGTTTTGAGCAGCACG ACTGACAGCACCAGTTCAACAACTACATCAACTTCGTCAATCAGTTCATCTTTACTTACT GATGGCAGAGTGGATATTTCTAAACTTCTGCTGGAGGTTCAAAAACTGTTGCGTGAGATG GTCACCACATTGCAAGATTATCTTCAGAAGCAATTGGCGCAAAGCTATGACATCCAAAA AGCCGTTTTTGAGAGCCAAAATAAAGCTATTGATGAGAAAAAAGCCGGTGCGACAGCCG CTCTGATTGGTGGTGCTATCTCATCTGTCCTGGGGATTTTAGGCTCTTTTGCTGCCATTAAT AGCGCAACTAAAGGCGCGAGTGATGTCGCTCAGCAAGCCGCTTCTACTTCTGCGAAGTC TATCGGTACAGTCTCTGAAGCTTCAACTAAAGCACTGGCGAAGGCTTCCGAAGGTATTGC AGATGCAGCAGATGATGCAGCTGGCGCAATGCAGCAAACTATCGCGACAGCTGCAAAA GCGGCCAGTCGTACATCCGGTATCACTGATGATGTTGCTACTTCGGCTCAGAAAGCTTCT CAGGTAGCTGAAGAGGCTGCTGATGCTGCTCAAGAATTAGCACAGAAGGCAGGATTATT AAGTCGCTTTACTGCTGCTGCCGGAAGGATTTCCGGTTCAACGCCATTTATTGTTGTTACC AGCCTTGCTGAAGGTACGAAAACATTGCCAACAACGATATCTGAATCTGTCAAGTCCAAT CATGATATCAATGAGCAGCGTGCTAAATCTGTAGAAAATCTTCAGGCGTCGAATTTAGAT ACCTACAAACAGGATGTTCGCAGAGCGCAGGATGATATCTCTAGCCGTCTACGTGATATG ACAACGACAGCCCGTGATCTTACTGACCTTATTAATCGCATGGGGCAAGCGGCTCGCTTA GCTGGGTAA

Genomic sequence - upstream and downstream of espB 

TTGGTACAACTGTGCTGAATAATGACGCAGCGTATTATAATGTGTTATCACAGGTTTCTGCTTTTGCTGTGGAA AATTTAACTCGACAAAGTGAGTACTTAAGTCAGAGTGCGAAGGCAGAGCTGGAAAAAGCTACTCTCGAGCTG CAAAACCAGGCGAATTATATACAGAGTGCTTCTCAGCTGATGTCTGATTCTGCGCGAGTGAATATCCGTATTGT CAGCGGTCGAGTTTAATTATTAAAGAGGCGTTTATTATGAATACTATCGATAATAACAATGCGGCAATCGCA GTTAATTCTGTTTTGAGCAGCACGACTGACAGCACCAGTTCAACAACTACATCAACTTCGTCAATCAGTTCAT CTTTACTTACTGATGGCAGAGTGGATATTTCTAAACTTCTGCTGGAGGTTCAAAAACTGTTGCGTGAGATGGTC ACCACATTGCAAGATTATCTTCAGAAGCAATTGGCGCAAAGCTATGACATCCAAAAAGCCGTTTTTGAGAGC CAAAATAAAGCTATTGATGAGAAAAAAGCCGGTGCGACAGCCGCTCTGATTGGTGGTGCTATCTCATCTGTCC TGGGGATTTTAGGCTCTTTTGCTGCCATTAATAGCGCAACTAAAGGCGCGAGTGATGTCGCTCAGCAAGCCGCTT CTACTTCTGCGAAGTCTATCGGTACAGTCTCTGAAGCTTCAACTAAAGCACTGGCGAAGGCTTCCGAAGGTATT GCAGATGCAGCAGATGATGCAGCTGGCGCAATGCAGCAAACTATCGCGACAGCTGCAAAAGCGGCCAGTCGTA CATCCGGTATCACTGATGATGTTGCTACTTCGGCTCAGAAAGCTTCTCAGGTAGCTGAAGAGGCTGCTGATGCTG CTCAAGAATTAGCACAGAAGGCAGGATTATTAAGTCGCTTTACTGCTGCTGCCGGAAGGATTTCCGGTTCAACG CCATTTATTGTTGTTACCAGCCTTGCTGAAGGTACGAAAACATTGCCAACAACGATATCTGAATCTGTCAAGT CCAATCATGATATCAATGAGCAGCGTGCTAAATCTGTAGAAAATCTTCAGGCGTCGAATTTAGATACCTACA AACAGGATGTTCGCAGAGCGCAGGATGATATCTCTAGCCGTCTACGTGATATGACAACGACAGCCCGTGATCTT ACTGACCTTATTAATCGCATGGGGCAAGCGGCTCGCTTAGCTGGGTAATTGATCATGGTCGATACGTTTAATGA TGAAGTGTTTAATTACTATCTTGAACAAAAAGGGTACACAATACAGAAGGAGTTTCTTTGTGGCAGTGCCTTT TTTATCGGATGGCGGATTGAGACACCTTTTTTTTCATTAGCGTACAGACTGGATGAACAAGAACTGATTTTGTG CTCTTTTGAAGCACGTAACCAAACAGGGCTTAACGGCCCTGTTTTATCACTGACTCGTTTGCTCGAAGAGTTGT ATCACCACTTTTCGGGTATTAAGAAAATCAGTGCGAT