EspF Papers

McNamara BP, Donnenberg MS. A novel proline-rich protein, EspF, is secreted from enteropathogenic Escherichia coli via the type III export pathway. FEMS Microbiol Lett. 1998 Sep 1;166(1):71-8.

McNamara BP, Koutsouris A, O'Connell CB, Nougayréde JP, Donnenberg MS, Hecht G. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function. J Clin Invest. 2001 Mar;107(5):621-9.

Crane JK, McNamara BP, Donnenberg MS. Role of EspF in host cell death induced by enteropathogenic Escherichia coli. Cell Microbiol. 2001 Apr;3(4):197-211.

Elliott SJ, O'Connell CB, Koutsouris A, Brinkley C, Donnenberg MS, Hecht G, Kaper JB. A gene from the locus of enterocyte effacement that is required for enteropathogenic Escherichia coli to increase tight-junction permeability encodes a chaperone for EspF. Infect Immun. 2002 May;70(5):2271-7.

Viswanathan VK, Lukic S, Koutsouris A, Miao R, Muza MM, Hecht G.Cytokeratin 18 interacts with the enteropathogenic Escherichia coli secreted protein F (EspF) and is redistributed after infection.Cell Microbiol. 2004 Oct;6(10):987-97.

Nougayrède JP, Donnenberg MS.Enteropathogenic Escherichia coli EspF is targeted to mitochondria and isrequired to initiate the mitochondrial death pathway.Cell Microbiol. 2004 Nov;6(11):1097-111.

Dean P, Kenny B.Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein.Mol Microbiol. 2004 Nov;54(3):665-75.

Nagai T, Abe A, Sasakawa C. Targeting of enteropathogenic Escherichia coli EspF to host mitochondria is essential for bacterial pathogenesis: critical role of the 16th leucine residuein EspF.J Biol Chem. 2005 Jan 28;280(4):2998-3011.

Shaw RK, Cleary J, Murphy MS, Frankel G, Knutton S.Interaction of enteropathogenic Escherichia coli with human intestinal mucosa: role of effector proteins in brush border remodeling and formation of attaching and effacing lesions.Infect Immun. 2005 Feb;73(2):1243-51.

Dean P, Maresca M, Schüller S, Phillips AD, Kenny B.Potent diarrheagenic mechanism mediated by the cooperative action of threeenteropathogenic Escherichia coli-injected effector proteins.Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1876-81.

Guttman JA, Li Y, Wickham ME, Deng W, Vogl AW, Finlay BB.Attaching and effacing pathogen-induced tight junction disruption in vivo.Cell Microbiol. 2006 Apr;8(4):634-45.

Marchès O, Batchelor M, Shaw RK, Patel A, Cummings N, Nagai T, Sasakawa C,Carlsson SR, Lundmark R, Cougoule C, Caron E, Knutton S, Connerton I, Frankel G. EspF of enteropathogenic Escherichia coli binds sorting nexin 9.J Bacteriol. 2006 Apr;188(8):3110-5.

Quitard S, Dean P, Maresca M, Kenny B.The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targeting. Cell Microbiol. 2006 Jun;8(6):972-81.

Nougayrède JP, Foster GH, Donnenberg MS.Enteropathogenic Escherichia coli effector EspF interacts with host protein Abcf2. Cell Microbiol. 2007 Mar;9(3):680-93.

Martinez-Argudo I, Sands C, Jepson MA. Translocation of enteropathogenic Escherichia coli across an in vitro M cell model is regulated by its type III secretion system. Cell Microbiol. 2007 Jun;9(6):1538-46.

Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24;178(7):1265-78.

Hodges K, Alto NM, Ramaswamy K, Dudeja PK, Hecht G. The enteropathogenic Escherichia coli effector protein EspF decreases sodium hydrogen exchanger 3 activity. Cell Microbiol. 2008 Aug;10(8):1735-45.

Peralta-Ramírez J, Hernandez JM, Manning-Cela R, Luna-Muñoz J, Garcia-Tovar C, Nougayréde JP, Oswald E, Navarro-Garcia F. EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability. Infect Immun. 2008 Sep;76(9):3854-68.