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EspZ

EPEC secreted protein Z (formerly SepZ)

EspZ Protein Sequence of EPEC strain E2348/69
Map NCBI

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MEAANLSPSGAVLPLAATINGNNPVDEKTGVMQSEGGTSRSVRILGGVLIGAGVLAAIGTGIAAMCVDDP
SQRLGLGIAAGVLGGVTTVAGGLAMKYA

EspZ publications

Homologues

EspZ Features

Secondary Structure.pdf

Colour Alignment

Phylogenetic Tree

REPORTED FUNCTIONS

Unknown

PROVEN BINDING PARTNERS

NA

SUBCELLULAR LOCATIONS

Localises to actin-pedestal regions

PHYSICO-CHEMICAL

98 amino acids; pI = 4.99; MW = 9.4 kDa;

DISCOVERED BY

James Kaper’s Lab (Kanack et al 2005) (formerly SepZ)

FUNCTIONAL MOTIFS

NA

Two publications on EspZ effector activities:

Kanack KJ, Crawford JA, Tatsuno I, Karmali MA, Kaper JB. SepZ/EspZ is secreted and translocated into HeLa cells by the enteropathogenic Escherichia coli type III secretion system. Infect Immun. 2005 Jul;73(7):4327-37.

Mills E, Baruch K, Charpentier X, Kobi S, Rosenshine I. Real-time analysis of effector translocation by the type III secretion system of enteropathogenic Escherichia coli. Cell Host Microbe. 2008 Feb 14;3(2):104-13

DNA Sequence of the espZ gene of EPEC strain E2348/69 

ATGGAAGCAGCAAATTTAAGCCCTTCTGGTGCAGTATTACCACTGGCAGCCACAATCAATGGAAATAATCCAGTG GATGAGAAGACAGGGGTGATGCAGTCAGAAGGTGGAACAAGTCGCAGCGTTAGAATCCTGGGTGGAGTTTTAATAG GTGCAGGTGTTCTAGCCGCTATCGGTACTGGTATCGCAGCAATGTGTGTTGACGACCCTTCACAAAGATTAGGCTTA GGAATCGCAGCCGGTGTATTAGGTGGCGTAACTACTGTTGCCGGCGGATTAGCGATGAAATATGCCTAA

Genomic sequence - upstream and downstream of espZ 

TAAATAAAAATCATTTCCCAACAATCTTAAAAACTCTTCAACATTTCTTTTAACTAAAAGATTCATCTGCAGGCTCTGAA GTAAGTATACGTGTGAATATTATTGCTTGAAAAAGCGTATTGGATAATATATACAGTATATGTACTTTATGTACATTGCA ACTATTTAAATAATATAATAGTTGCCTATGGGATAATTTGGTTATTTATAACCAGGTAAATGTCTAAATTAGACAAAAGG AGAAAGATCAATGGAAGCAGCAAATTTAAGCCCTTCTGGTGCAGTATTACCACTGGCAGCCACAATCAATGGAAATAA TCCAGTGGATGAGAAGACAGGGGTGATGCAGTCAGAAGGTGGAACAAGTCGCAGCGTTAGAATCCTGGGTGGAGTTTT AATAGGTGCAGGTGTTCTAGCCGCTATCGGTACTGGTATCGCAGCAATGTGTGTTGACGACCCTTCACAAAGATTAGGC TTAGGAATCGCAGCCGGTGTATTAGGTGGCGTAACTACTGTTGCCGGCGGATTAGCGATGAAATATGCCTAATCATCGC ATCGCATAAAAATAGAGAGGTAATGGATGCATTATGCTATTGCCTCTCTCATGAAAAGAGACTAACAGTAAATATGAAT AATATTAATCAATCGGAAAACATTAATATTCAGTTAAATAAAGCATCCCAAACAAATGTCGTTGATGAGCATATCCCGT TAGCATCAACCCCCTCTGCAGCCGGAGCGGCTCAGTTTCTTGATCAATTACTCCCTAAAACGGCGGGAGTGTCTTCCCCA GAACAAGTGTTGATTGAGGAAATTAAAAAGCGACATCTTGCAACAATGA