Effector Link
[EspZ] [EspF] [EspH] [Tir] [EspG] [EspB]

Map

mitochondria associated protein

Map Protein Sequence of EPEC strain E2348/69
Map NCBI

Back to EPEC Lab Page

MFSPTAMVGRALAQAVTQTLRPAVTKAATQAGMAASGMRFTPMQSNLMINHGKLTTQLLQAV AKQTGSSDTQQWFKQEQITFLSRAVNKTVDDYCMSNNSAISKETKCRIFKEVESAIQQPLDMNC AQSSISHFLQSNKYFNQKVDEQCGKGVDPITRFNTQTKLIEQVSREIFEQNFSTAKISDIKALTEK AIADNVQDTRL

Map publications

Homologues

Map Features

Secondary Structure.pdf

Colour Alignment

Phylogenetic Tree

REPORTED FUNCTIONS

Filopodia formation, Tight junction disruption, Microvilli effacement, Mitochondrial dysfunction

PROVEN BINDING PARTNERS

To be added

SUBCELLULAR LOCATIONS

Mitochondria, plasma membrane, cytoplasm

PHYSICO-CHEMICAL

203 amino acids, 22.5 kDa, pI 9.08,

DISCOVERED BY

Brendan Kenny’s Lab (Kenny and Jepson, 2000)

FUNCTIONAL MOTIFS

C-terminal PDZ class I domain (C-terminal DTRL)  Simpson et al (2006)

Mitochondrial targeting sequence (1-41) Papatheodorou et al (2006),  Kenny and Jepson, (2000) and predicted by MITOPROT

DNA Sequence of the map gene of EPEC strain E2348/69 

ATGTTTAGTCCAACGGCAATGGTAGGTAGAGCGTTAGCTCAGGCGGTTACACAAACTCTTAGACCCGCTGTAACCA AGGCTGCGACGCAAGCGGGCATGGCAGCCAGTGGTATGAGGTTCACACCTATGCAGTCGAACCTTATGATTAATCAT GGCAAACTGACTACCCAGCTACTACAGGCCGTAGCCAAACAAACTGGTAGTAGTGATACCCAGCAATGGTTCAAGC AAGAGCAGATTACTTTTCTATCCAGAGCAGTAAACAAAACTGTGGATGACTATTGCATGAGTAATAATTCGGCAA TTAGTAAGGAGACTAAATGTCGCATTTTTAAAGAGGTTGAAAGCGCGATACAACAGCCTCTCGATATGAACTGTGC ACAATCATCAATTAGTCACTTTTTGCAATCCAATAAATACTTTAATCAGAAAGTTGATGAGCAGTGTGGTAAAGG AGTGGATCCCATTACACGTTTTAACACTCAAACCAAATTGATAGAACAAGTCTCACGCGAAATCTTTGAACAGAA TTTTAGCACCGCGAAAATCAGTGATATCAAGGCTCTAACTGAGAAGGCGATTGCAGACAATGTGCAGGATACTCGG CTGTAG

Genomic sequence - upstream and downstream of map 

TTCATAGGTAATTTATTTGTGAGTTCTTACACAAATAACAAGGAAAAAATATAACATGTAAGTAATAATGTTGCATATTCATG ATAGCATATGATAAATGTAGTGCAACCACCTATAAATAGTGCTGGAGGAAAAGTTCTGGAGGAAAATTAAAATCATAAAATAA TATTATAGTTTTATTTATTCGTTTTATTTTTATAGGTGTAAATGTTTTTTATGTAATTTATAAAGGTTTATAGCATGTTTAGT CCAACGGCAATGGTAGGTAGAGCGTTAGCTCAGGCGGTTACACAAACTCTTAGACCCGCTGTAACCAAGGCTGCGACGCAAGC GGGCATGGCAGCCAGTGGTATGAGGTTCACACCTATGCAGTCGAACCTTATGATTAATCATGGCAAACTGACTACCCAGCTAC TACAGGCCGTAGCCAAACAAACTGGTAGTAGTGATACCCAGCAATGGTTCAAGCAAGAGCAGATTACTTTTCTATCCAGAGCA GTAAACAAAACTGTGGATGACTATTGCATGAGTAATAATTCGGCAATTAGTAAGGAGACTAAATGTCGCATTTTTAAAGAGGT TGAAAGCGCGATACAACAGCCTCTCGATATGAACTGTGCACAATCATCAATTAGTCACTTTTTGCAATCCAATAAATACTTTA ATCAGAAAGTTGATGAGCAGTGTGGTAAAGGAGTGGATCCCATTACACGTTTTAACACTCAAACCAAATTGATAGAACAAGTC TCACGCGAAATCTTTGAACAGAATTTTAGCACCGCGAAAATCAGTGATATCAAGGCTCTAACTGAGAAGGCGATTGCAGACAA TGTGCAGGATACTCGGCTGTAGGGGGAAACTTACTGCGCTGTTATTTTTTTTCTTGATGCAAAAAGGTCTCTATAGACGTTTA AAATAAAATATTATTTTTCAATACACAATTAAATTTCTGCATATAAAAATTATAATTATTTTTTTTCGATAATTATATAATGA TTTTGATTATGTGATTTTTTAGTTGGAAATACAGACATGCATTTCTGGTGCGTTATTTTGCTTGCATCAAAAATTATACTGTG ATTTATTTGGTTTATGCTCAGTTGTTTTATCGGCTGCATAC