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Enteropathogenic E.coli (EPEC) Effectors 

EPEC possesses at least 21 putative effectors. Seven effector genes (including the translocator EspB) are encoded on the Locus of Enterocyte Effacement (LEE) while other effectors are found in non-LEE Pathogenicity Islands (PP2, PP4, Pp6, IE2, IE5, IE6) located elsewhere on the chromosome. For more information of the identity and composition of non-LEE islands see the genome paper.   

The LEE effectors

The Locus of Enterocyte Effacement is a pathogenicity island located on the EPEC chromosome and is shown below. The genomic DNA sequence of the LEE can be found here at the NCBI website. The LEE carries the genes for EPEC’s only type three secretion system, whic enable EPEC to deliver effectors proteins into the host cell. The LEE also carries 7 effector genes (including EspB) are shown below in red. For information on each effector please click the corresponding arrow in the LEE or click the effector icon below the island.  

The LEE Genomic Island - click on an effector gene in the map for more info
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EspF

Map

EspH

EspZ

Tir

EspB

EspG

Taken  from Dean et al 2005
[EspF] [EspB] [EspG] [EspH] [Map] [EspZ] [Tir]

The non-LEE Pathogenicity Islands

Genomic sequencing (see paper) and various experimental studies have  shown EPEC to possess numerous pathogenicity Islands, many containing effector genes. The 6 effector-containing Islands are given below. Click on an effector gene to find out more information.
NonLEEislands

Taken  from Dean and Kenny 2009

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