Selected Papers from the Lab

Please contact me if you would like a PDF copy of any of the following publications.

• Dean P. Functional domains and motifs of bacterial type III effector proteins and their roles in infection.FEMS Microbio. Rev. 2011 Apr 25.

• Dean P* and Kenny B. Cell-surface nucleolin is sequestered into EPEC microcolonies and may play a role during infection. Microbiology 2011 Jun;157(Pt 6):1761-7. *Corresponding author

• Holmes A, Mühlen S, Roe AJ, Dean P*.The EspF effector - a bacterial pathogen's Swiss army knife. Infect Immun. 2010 Aug 2. *Corresponding author

• *Dean, P,  Scott, JA, Knox, AA, Quitard, S, Watkins, NJ and Kenny, B. The Enteropathogenic E. coli Effector EspF Targets and Disrupts the Nucleolus by a Process Regulated  by Mitochondrial Dysfunction. PLOS Pathogens 2010. *Corresponding author. See our nucleolar page

• *Dean P, Muehlen S, Quitard S, Kenny B. The bacterial effectors EspG and EspG2 induce a  destructive calpain activity that is kept in check by the co-delivered Tir effector. Cell. Microbiol. 2010 Mar 25.*Corresponding author

• *Dean P, Kenny B. The effector repertoire of enteropathogenic E. coli: ganging up on the host cell. Curr Opin Microbiol. 2009 Feb;12(1):101-9.  *Corresponding author        

• Iguchi A, Thomson NR, Ogura Y, Saunders D, Ooka T, Henderson IR, Harris D, Asadulghani M, Kurokawa K, Dean P, Kenny B, Quail MA, Thurston S, Dougan G, Hayashi T, Parkhill J, Frankel G. Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69. J Bacteriol. 2009 Jan;191(1):347-54

• Ruchaud-Sparagano MH, Maresca M, Kenny B.Enteropathogenic Escherichia coli (EPEC) inactivate innate immune responses prior to compromising epithelial barrier function.Cell Microbiol. 2007 Aug;9(8):1909-21.

• Quitard S, Dean P, Maresca M, Kenny B.The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targeting.Cell Microbiol. 2006 Jun;8(6):972-81.

• Dean P, Maresca M, Schüller S, Phillips AD, Kenny B.Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins.Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1876-81.

• Maresca M, Miller D, Quitard S, Dean P, Kenny B.Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model system.Cell Microbiol. 2005 Dec;7(12):1749-62.

• Dean P, Maresca M, Kenny B.EPEC's weapons of mass subversion.Curr Opin Microbiol. 2005 Feb;8(1):28-34. Review.

• Dean P, Kenny B. Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein.Mol Microbiol. 2004 Nov;54(3):665-75.

• Jepson MA, Pellegrin S, Peto L, Banbury DN, Leard AD, Mellor H, Kenny B.Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic Escherichia coli (EPEC) into non-phagocytic cells.Cell Microbiol. 2003 Nov;5(11):773-83.

• Hawrani A, Dempsey CE, Banfield MJ, Scott DJ, Clarke AR, Kenny B.Effect of protein kinase A-mediated phosphorylation on the structure and association properties of the enteropathogenic Escherichia coli Tir virulence protein.J Biol Chem. 2003 Jul 11;278(28):25839-46.

• Kenny B, Ellis S, Leard AD, Warawa J, Mellor H, Jepson MA.Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules.Mol Microbiol. 2002 May;44(4):1095-1107.

• Warawa J, Kenny B.Phosphoserine modification of the enteropathogenic Escherichia coli Tir molecule is required to trigger conformational changes in Tir and efficient pedestal elongation. Mol Microbiol. 2001 Dec;42(5):1269-80.

• Kenny B.The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologue.Cell Microbiol. 2001 Aug;3(8):499-510.

• Kenny B, Warawa J.Enteropathogenic Escherichia coli (EPEC) Tir receptor molecule does not undergo full  modification when introduced into host cells by EPEC-independent mechanisms. Infect Immun. 2001 Mar;69(3):1444-53.

• Kenny B, Jepson M. Targeting of an enteropathogenic Escherichia coli (EPEC) effector protein to host mitochondria.Cell Microbiol. 2000 Dec;2(6):579-90.