Newcastle University

The 3Rs Cancer Research Lab at Newcastle University develops advanced human relevant models to study prostate cancer biology, disease progression, and therapy resistance. Our work aims to improve the translational relevance of preclinical cancer research while reducing reliance on animal experimentation.

We use stem cell derived and patient derived organoid systems to investigate how epithelial organisation, signalling pathways, and genetic alterations shape prostate cancer behaviour. By combining organoid biology, genome engineering, advanced imaging, and transcriptomic approaches, we develop scalable and predictive platforms that support precision medicine and therapeutic discovery.

A central focus of the lab is understanding mechanisms of therapy resistance in advanced prostate cancer, including the role of the primary cilium as a regulator of signalling and treatment response. Our research is supported by the NC3Rs and Prostate Cancer UK and is carried out in close collaboration with academic, clinical, and industry partners.

The lab is committed to responsible and ethical research practices, interdisciplinary collaboration, and the training of early career researchers. We welcome enquiries from prospective PhD and MSc students, postdoctoral researchers, and collaborators interested in organoid models, prostate cancer, and human relevant preclinical science.