The research programme of the 3Rs Cancer Research Lab focuses on understanding prostate cancer biology and therapy resistance using advanced human relevant preclinical models. Our work is grounded in translational cancer research and aims to address clinically relevant questions that are difficult to study using conventional systems.

A key focus of the lab is the development of prostate organoid platforms derived from induced pluripotent stem cells and patient material. These models enable controlled investigation of epithelial organisation, lineage relationships, and signalling pathways in both normal and disease contexts. By using xeno free and scalable organoid systems, we improve experimental reproducibility and support more ethical research practices.

Current projects explore mechanisms of therapy resistance in advanced prostate cancer, including how genetic alterations, tissue architecture, and androgen signalling influence treatment response. In particular, we are interested in the role of the primary cilium as a regulator of epithelial signalling and cellular behaviour.

Our research integrates stem cell biology, genome engineering, advanced imaging, and transcriptomic approaches. We work closely with academic, clinical, and industry partners to ensure that our models remain clinically relevant and support the development of more predictive preclinical tools.