{"id":6,"date":"2019-03-13T14:07:20","date_gmt":"2019-03-13T14:07:20","guid":{"rendered":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/?page_id=6"},"modified":"2025-09-02T10:03:19","modified_gmt":"2025-09-02T10:03:19","slug":"james-c-knight","status":"publish","type":"page","link":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/","title":{"rendered":"Dr. James C Knight"},"content":{"rendered":"\n
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I am a lecturer in radiochemistry in the School of Natural and Environmental Sciences at Newcastle University. My research focusses on the synthesis and preclinical evaluation of radiopharmaceuticals for imaging and therapeutic applications. <\/p>\n\n\n\n

I am the Head of Admissions for MSc Chemistry and Drug Chemistry programmes and the lead for radiochemistry within the Discovery of Medicines research theme in the Faculty of Medical Sciences. I was previously the Degree Programme Director for MSc Drug Chemistry.<\/p>\n\n\n\n

I have authored 85 publications (with >1500 citations) in this area and have co-authored 2 textbooks on click chemistry and its role in radiochemistry. I also sit on the editorial board of several peer-reviewed journals.<\/p>\n\n\n\n

My research has been generously supported by Bone Cancer Research Trust, EPSRC, Orthopaedic Research UK, UK SPINE, Wellcome Trust, and NIHR.<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n

Latest Publications<\/h1>\n\n\n\n

83. Toni A. Pringle and James C. Knight*. The Effects of Buffer, pH, and Temperature Upon SPAAC Reaction Rates. Organic and Biomolecular Chemistry, 2025,<\/strong> in press.<\/p>\n\n\n

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82. Toni A. Pringle, Erik-Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight*, Saimir Luli*. Synthesis and Preclinical Evaluation of a 89Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury<\/a>. Scientific Reports, 2024<\/strong>, 14, 633.<\/p>\n\n\n

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81. Stavros Melemenidis, James C. Knight, Veerle Kersemans, Francisco Perez-Balderas, Niloufar Zarghami, Manuel Sarmiento Soto, Bart Cornelissen, Ruth J. Muschel, and Nicola R. Sibson*. 2024. In Vivo PET Detection of Lung Micrometastasis in Mice by Targeting Endothelial VCAM-1 Using a Dual-Contrast PET\/MRI Probe.<\/a> International Journal of Molecular Sciences<\/strong>, 2024<\/strong>, 25(13), 7160, 1-19.<\/p>\n\n\n

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80. Lydia Cooke, Katie Gristwood, Kate Adamson, Mark Sims, Michael Deary, Dawn Bruce, Antony Antoniou, Hannah Walden, James C. Knight, Timoth\u00e9 Antoine-Brunet, Marie Joly, David Goyard, Pierre-Henri Lano\u00eb, Nathalie Berthet, Valery Kozhevnikov*. Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Strain Alkynes<\/a>. Dalton Transactions, 2024<\/strong>, 53(37), 15501<\/p>\n\n\n

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79. Tracey Luu, Katie Gristwood, James C. Knight*, and Manuela J\u00f6rg*. Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications. Bioconjugate Chemistry, 2024<\/strong>, 35(6), 715-731. doi.org\/10.1021\/acs.bioconjchem.4c00084<\/a><\/p>\n\n\n

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78. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. Synthesis and in vitro evaluation of a HER2-specific immunoSCIFI probe<\/a>. ACS Omega, 2023<\/strong>, 8, <\/em>50, 47905-47912. (journal cover).<\/p>\n\n\n

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77. Toni A. Pringle, Oliver Coleman, Akane Kawamura, James C. Knight*. The Influence of Degree of Labelling upon Cellular Internalisation of Antibody-Cell Penetrating Peptide Conjugates<\/a>. RSC Advances, 2022<\/strong>, 12, 27716-27722.<\/p>\n\n\n

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76. Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen Blair, Kenneth S. Rankin*, James C. Knight*. Synthesis and In Vivo Evaluation of a Site-Specifically Labelled Radioimmunoconjugate for Dual-Modal (PET\/NIRF) Imaging of MT1-MMP in Sarcomas<\/a>. Bioconjugate Chemistry, 2022,<\/strong> 33(8), 1564-1573. (journal cover).<\/p>\n\n\n

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75. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. In situ excitation of BODIPY fluorophores by Cerenkov Luminescence<\/a>. Chem. Commun., 2022<\/strong>, 58, 11689-11692.<\/p>\n\n\n

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<\/p>\n","protected":false},"excerpt":{"rendered":"

I am a lecturer in radiochemistry in the School of Natural and Environmental Sciences at Newcastle University. My research focusses on the synthesis and preclinical evaluation of radiopharmaceuticals for imaging and therapeutic applications. I am the Head of Admissions for MSc Chemistry and Drug Chemistry programmes and the lead for radiochemistry within the Discovery of […]<\/a><\/p>\n","protected":false},"author":3949,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry","post-seq-1","post-parity-odd","meta-position-corners","fix"],"_links":{"self":[{"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/users\/3949"}],"replies":[{"embeddable":true,"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":51,"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":539,"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/pages\/6\/revisions\/539"}],"wp:attachment":[{"href":"https:\/\/www.staff.ncl.ac.uk\/jamesknight2\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}