{"id":124,"date":"2021-08-05T15:42:05","date_gmt":"2021-08-05T15:42:05","guid":{"rendered":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/?p=124"},"modified":"2022-03-18T09:59:09","modified_gmt":"2022-03-18T09:59:09","slug":"paper-published-mathematical-modelling-of-oct4-in-human-pluripotent-stem-cells","status":"publish","type":"post","link":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/2021\/08\/05\/paper-published-mathematical-modelling-of-oct4-in-human-pluripotent-stem-cells\/","title":{"rendered":"Paper published: mathematical modelling of OCT4 in human pluripotent stem cells"},"content":{"rendered":"\n<p>Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in PLoS ONE. <\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0254991\" target=\"_blank\">A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells<\/a><\/p>\n\n\n\n<p>We use fractional Brownian motion and the stochastic logistic equation to describe the temporal properties of OCT4 in a growing hESC colony. We particularly look at using a time-dependent carrying capacity or an Allee effect to capture the decline in OCT4 upon cell differentiation, pictured below! <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"959\" height=\"1024\" src=\"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/files\/2021\/08\/FigureS6-959x1024.png\" alt=\"\" class=\"wp-image-125\" srcset=\"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/files\/2021\/08\/FigureS6-959x1024.png 959w, https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/files\/2021\/08\/FigureS6-281x300.png 281w, https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/files\/2021\/08\/FigureS6-768x820.png 768w, https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/files\/2021\/08\/FigureS6-1439x1536.png 1439w, https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/files\/2021\/08\/FigureS6-1919x2048.png 1919w\" sizes=\"auto, (max-width: 959px) 100vw, 959px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in PLoS ONE. A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells We use fractional Brownian motion and the stochastic logistic equation to describe the temporal properties of OCT4 in a growing hESC colony. &hellip; <a href=\"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/2021\/08\/05\/paper-published-mathematical-modelling-of-oct4-in-human-pluripotent-stem-cells\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Paper published: mathematical modelling of OCT4 in human pluripotent stem cells<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":4649,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[6,9,8,10],"class_list":["post-124","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-mathematical-biology","tag-mathematical-modelling","tag-oct4","tag-stem-cells"],"_links":{"self":[{"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/posts\/124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/users\/4649"}],"replies":[{"embeddable":true,"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/comments?post=124"}],"version-history":[{"count":1,"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/posts\/124\/revisions"}],"predecessor-version":[{"id":126,"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/posts\/124\/revisions\/126"}],"wp:attachment":[{"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/media?parent=124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/categories?post=124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.staff.ncl.ac.uk\/laurawadkin\/wp-json\/wp\/v2\/tags?post=124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}