I am currently based in at Newcastle University Medicine Malaysia (NUMed) where I am the Dean of Biomedical Sciences (BMS).
Previous to NUMed I worked at the School of Biomedical Sciences for 14 years where I taught on thriteen degree programmes: Biological Sciences, BSc Deferred Choice; Biochemistry, BSc; Biochemistry with Immunology, BSc; Biomedical Sciences, BSc; Biomedical Sciences with Management, BSc; Biotechnology, BSc; Biotechnology, BSc with industrial placement year; Biomedical Genetics, BSc; Medical Microbiology and Immunology, BSc; Pharmacology, BSc; Physiological Sciences, BSc; MSci Biomedical Sciences (Integrated Masters) (4 year programme) and MSc Bioinformatics. I was also leader for 5 modules taught in the School.
The subject areas I covered, and still teach at NUMed, are basic laboratory skills (biochemistry, microbiology, cell biology, and pharmacology), academic skills (e.g. maths, essay writing, informatics skills), bioinformatics, genetics, pharmacology, biochemistry, microbiology, and cell signalling. My 'specialist' subject areas include insulin signalling, G-protein coupled receptors, bioinformatics, proteomics, and protein trafficking.
My research interests are in signal transduction, protein trafficking, proteomics and bioinformatics. In my previous positions I have examined intracellular signalling in the Müller cells of the retina, the phosphorylation of the alpha subunit of the heterotrimeric G-protein Gi-2 in hepatocyte, and the trafficking of the insulin-responsive vesicles that contain the glucose transporter GLUT4.
Image now available on Figshare
Intra-cellular protein trafficking and signalling: I have worked on signalling systems and protein trafficking for a number of years. In particular I am interested in the regulation of the sorting and trafficking of the glucose transporter GLUT4 and how diabetes causes a dysfunction in the insulin-signalling pathway and therefore a failure of GLUT4 to translocate to the plasma-membrane. My interest in trafficking and signalling also drive, and provide the data for, my other research interests.
Proteomics: Previous, and current, projects have included a large element of proteomics. The analysis of the protein components of the GLUT4 vesicles was a proteomics project, as was my work on the characterisation of the protein phosphorylation sites of alpha Gi2. I was also a co-founder of the proteomics facility at Newcastle University.
Bioinformatics: Throughout my research career I have used available computing facilities/systems to help with the analysis and design of experiments. Over the years I have developed a range of bioinformatics and computing skills including programming in php, C and objective-C as well as basic system administration and MySQL skills. I also helped establish the Bioinformatics Support Unit at Newcastle University.
On-going collaborations: I am currently involved in a number of on-going collaborations in bioinformatics and proteomics.