Computer Exercises
Workshop on Methods for Genome-wide Association Studies

25th May 2017
The Chinese University of Hong Kong


The lecture slides are available here: HongKongGWAS.pdf

Software Required

To participate in the computer exercises you will need to download several pieces of software. I recommend that you try downloading these and getting them running before the workshop. If you are using a Windows computer, you will need to run the programs using the command line or MS-DOS prompt. Some useful instructions for doing this can be found at:
http://www.computerhope.com/issues/chdos.htm

You will also need to download the following software to your computers:

PLINK:

If you are working on Windows (MS-DOS) you can hopefully just save the following file to an appropriate folder on your machine:

plink.exe

[Right click, select Save Target As, and navigate through to save it in the desired folder].

Alternatively you can download PLINK version 1.07 from:
http://zzz.bwh.harvard.edu/plink/download.shtml

(Note that we will be using the command-line version, not the gPLINK GUI).

Or else you can download the newer version, PLINK 1.90, from:
https://www.cog-genomics.org/plink/1.9/

FaST-LMM:

You will also need to get FaST-LMM running on your computer in order to do the last exercise. If you are working on Windows (MS-DOS) you can hopefully just save the following files to an appropriate folder on your machine:

FastLmmC.exe
libiomp5md.dll

[Right click, select Save Target As, and navigate through to save it in the desired folder].

Alternatively, FaST-LMM can be obtained from:
http://research.microsoft.com/en-us/downloads/aa90ccfb-b2a8-4872-ba00-32419913ca14/

R:

You will also need to get R running on your computer in order to visualise the results of your analyses. R can be obtained from:
http://www.r-project.org/


Computer Exercises:


Case/control association analysis in PLINK

Data management in PLINK

Family-based (TDT) GWAS analysis in PLINK

Linear mixed model GWAS analysis in FaST-LMM