Publication data

Click here for access to the summary statistics and LD matrices used in Gjoka and Cordell (2024) "Fine-mapping the results from genome-wide association studies of primary biliary cholangitis using SuSiE and h2-D2".

Click here for access to the CpG methylation prediction models developed by Fryett et al. (2022) "Investigating the prediction of CpG methylation levels from SNP genotype data to help elucidate relationships between methylation, gene expression and complex traits".

Click here for access to published results from Cordell et al. (2013) "Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot".

Selected Publications

These are the most relevant of my publications, up to 2017. For an almost complete list, do a PubMed search on Cordell HJ. For a complete list, plus some spurious entries from H.K. Cordell, do a PubMed search on Cordell H.

  • Asimit JL, Payne F, Morris AP, Cordell HJ, Barroso I (2017) A two-stage inter-rater approach for enrichment testing of variants associated with multiple traits. Eur J Hum Genet. doi: 10.1038/ejhg.2016.171. [Epub ahead of print]. PMID: 28000695

  • Liu W, Anstee QM, Wang X, Gawrieh S, Gamazon ER, Athinarayanan S, Liu YL, Darlay R, Cordell HJ, Daly AK, Day CP, Chalasani N (2017) Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans. Aging doi: 10.18632/aging.101067. [Epub ahead of print]. PMID: 27744419

  • Howey RA, Eu-Ahsunthornwattana J, Darlay R, Cordell HJ (2016) Examination of previously identified associations within the Genetic Analysis Workshop 19 data. BMC Proc 10(Suppl 7):97-101. PMID: 27980618

  • Ainsworth HF, Cordell HJ (2016) Using gene expression data to identify causal pathways between genotype and phenotype in a complex disease: application to Genetic Analysis Workshop 19. BMC Proc 10(Suppl 7):79-84. PMID: 27980615

  • Balzani A, Cordell HJ, Sutcliffe E, Edwards SA (2016) Heritability of udder morphology and colostrum quality traits in swine. J Anim Sci 94(9):3636-3644. PMID: 27898925

  • Babran N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium., Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, Ben-Avraham D, Berger K, Bergman A, Bertram L, Bielak LF, Bjornsdottir G, Bonder MJ, Broer L, Bui M, Barbieri C, Cavadino A, Chavarro JE, Turman C, Concas MP, Cordell HJ, Davies G, Eibich P, Eriksson N, Esko T, Eriksson J, Falahi F, Felix JF, Fontana MA, Franke L, Gandin I, Gaskins AJ, Gieger C, Gunderson EP, Guo X, Hayward C, He C, Hofer E, Huang H, Joshi PK, Kanoni S, Karlsson R, Kiechl S, Kifley A, Kluttig A, Kraft P, Lagou V, Lecoeur C, Lahti J, Li-Gao R, Lind PA, Liu T, Makalic E, Mamasoula C, Matteson L, Mbarek H, McArdle PF, McMahon G, Meddens SF, Mihailov E, Miller M, Missmer SA, Monnereau C, van der Most PJ, Myhre R, Nalls MA, Nutile T, Kalafati IP, Porcu E, Prokopenko I, Rajan KB, Rich-Edwards J, Rietveld CA, Robino A, Rose LM, Rueedi R, Ryan KA, Saba Y, Schmidt D, Smith JA, Stolk L, Streeten E, Tönjes A, Thorleifsson G, Ulivi S, Wedenoja J, Wellmann J, Willeit P, Yao J, Yengo L, Zhao JH, Zhao W, Zhernakova DV, Amin N, Andrews H, Balkau B, Barzilai N, Bergmann S, Biino G, Bisgaard H, Bønnelykke K, Boomsma DI, Buring JE, Campbell H, Cappellani S, Ciullo M, Cox SR, Cucca F, Toniolo D, Davey-Smith G, Deary IJ, Dedoussis G, Deloukas P, van Duijn CM, de Geus EJ, Eriksson JG, Evans DA, Faul JD, Sala CF, Froguel P, Gasparini P, Girotto G, Grabe HJ, Greiser KH, Groenen PJ, de Haan HG, Haerting J, Harris TB, Heath AC, Heikkilä K, Hofman A, Homuth G, Holliday EG, Hopper J, Hyppönen E, Jacobsson B, Jaddoe VW, Johannesson M, Jugessur A, Kähönen M, Kajantie E, Kardia SL, Keavney B, Kolcic I, Koponen P, Kovacs P, Kronenberg F, Kutalik Z, La Bianca M, Lachance G, Iacono WG, Lai S, Lehtimäki T, Liewald DC; LifeLines Cohort Study., Lindgren CM, Liu Y, Luben R, Lucht M, Luoto R, Magnus P, Magnusson PK, Martin NG, McGue M, McQuillan R, Medland SE, Meisinger C, Mellström D, Metspalu A, Traglia M, Milani L, Mitchell P, Montgomery GW, Mook-Kanamori D, de Mutsert R, Nohr EA, Ohlsson C, Olsen J, Ong KK, Paternoster L, Pattie A, Penninx BW, Perola M, Peyser PA, Pirastu M, Polasek O, Power C, Kaprio J, Raffel LJ, Räikkönen K, Raitakari O, Ridker PM, Ring SM, Roll K, Rudan I, Ruggiero D, Rujescu D, Salomaa V, Schlessinger D, Schmidt H, Schmidt R, Schupf N, Smit J, Sorice R, Spector TD, Starr JM, Stöckl D, Strauch K, Stumvoll M, Swertz MA, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tung JY, Uitterlinden AG, Vaccargiu S, Viikari J, Vitart V, Völzke H, Vollenweider P, Vuckovic D, Waage J, Wagner GG, Wang JJ, Wareham NJ, Weir DR, Willemsen G, Willeit J, Wright AF, Zondervan KT, Stefansson K, Krueger RF, Lee JJ, Benjamin DJ, Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC.(2016) Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet 48(12):1462-1472. PMID: 27798627

  • Hanchard NA, Swaminathan S, Bucasas K, Furthner D, Fernbach S, Azamian MS, Wang X, Lewin M, Towbin JA, D'Alessandro LC, Morris SA, Dreyer W, Denfield S, Ayres NA, Franklin WJ, Justino H, Lantin-Hermoso MR, Ocampo EC, Santos AB, Parekh D, Moodie D, Jeewa A, Lawrence E, Allen HD, Penny DJ, Fraser CD, Lupski JR, Popoola M, Wadhwa L, Brook JD, Bu'Lock FA, Bhattacharya S, Lalani SR, Zender GA, Fitzgerald-Butt SM, Bowman J, Corsmeier D, White P, Lecerf K, Zapata G, Hernandez P, Goodship JA, Garg V, Keavney BD, Leal SM, Cordell HJ, Belmont JW, McBride K (2016)A genome-wide association study of congenital cardiovascular left-sided lesions shows association with a locus on chromosome 20. Hum Molec Genet 25(11):2331-2341. PMID: 26965164

  • Balzani A, Cordell HJ, Edwards SA (2016) Relationship of sow udder morphology with piglet suckling behavior and teat access. Theriogenology 86(8):1913-20. PMID: 27444421

  • Baurecht H, Hotze M, Rodríguez E, Manz J, Weidinger S, Cordell HJ, Augustin T, Strauch K (2016) Compare and Contrast Meta Analysis (CCMA): A Method for Identification of Pleiotropic Loci in Genome-Wide Association Studies. PLoS One 11(5):e0154872. PMID: 27149374

  • Balzani A, Cordell HJ, Sutcliffe E, Edwards SA (2016) Sources of variation in udder morphology of sows. J Anim Sci 94(1):394-400. PMID: 26812344

  • Balzani A, Cordell HJ, Edwards SA (2016) Evaluation of an on-farm method to assess colostrum IgG content in sows. Animal 10(4):643-8. PMID: 26554447

  • Balzani A, Cordell HJ, Edwards SA (2016) Development of a methodology to describe udder conformation in sows. Animal 10(3):432-9. PMID: 26536824

  • Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J (2015) Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk. Hum Mol Genet 24(25):7432-44. PMID: 26464490.

  • Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D, Qian DC, Floyd JA, Morley KI, Prati D, Lleo A, Cusi D; Canadian-US PBC Consortium; Italian PBC Genetics Study Group; UK-PBC Consortium, Gershwin ME, Anderson CA, Lazaridis KN, Invernizzi P, Seldin MF, Sandford RN, Amos CI, Siminovitch KA (2015) International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways. Nat Commun 6:8019. PMID: 26394269.

  • Howey R, Mamasoula C, Töpf A, Nudel R, Goodship JA, Keavney BD, Cordell HJ (2015) Increased Power for Detection of Parent-of-Origin Effects via the Use of Haplotype Estimation. Am J Hum Genet 97(3):419-34. PMID: 26320892.

  • Knowles JW, Xie W, Zhang Z, Chennamsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, Guo X, Abbasi F, Greenawalt DM, Lum P, Molony C, Lind L, Lindgren C, Raffel LJ, Tsao PS; RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium.; EUGENE2 (European Network on Functional Genomics of Type 2 Diabetes) Study.; GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium.; SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study., Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T (2015) Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 125(4):1739-51. PMID: 25798622

  • Anderson D, Cordell HJ, Fakiola M, Francis RW, Syn G, Scaman ES, Davis E, Miles SJ, McLeay T, Jamieson SE, Blackwell JM (2015) First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes. PLoS One 0(3):e0119333. PMID: 25760438.

  • Baurecht H, Hotze M, Brand S, Büning C, Cormican P, Corvin A, Ellinghaus D, Ellinghaus E, Esparza-Gordillo J, Fölster-Holst R, Franke A, Gieger C, Hubner N, Illig T, Irvine AD, Kabesch M, Lee YA, Lieb W, Marenholz I, McLean WH, Morris DW, Mrowietz U, Nair R, Nöthen MM, Novak N, O'Regan GM; PAGE Consortium, Schreiber S, Smith C, Strauch K, Stuart PE, Trembath R, Tsoi LC, Weichenthal M, Barker J, Elder JT, Weidinger S, Cordell HJ, Brown SJ (2015) Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. Am J Hum Genet 6(1):104-20. PMID: 25574825.

  • Eu-Ahsunthornwattana J, Miller EN, Fakiola M; Wellcome Trust Case Control Consortium 2, Jeronimo SM, Blackwell JM, Cordell HJ (2014) Comparison of methods to account for relatedness in genome-wide association studies with family-based data. PLoS Genet 10(7):e1004445. PMID: 25033443.

  • Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Gudbjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, van den Akker EB, Bohringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJ, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, Mcnerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefansson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RG, Willemsen G, Samani NJ, Galan P, Sorensen TI, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJ, Christensen K, Nebel A, Stefansson K, Metspalu A, Magnusson P, Blanche H, Christiansen L, Kirkwood TB, van Duijn CM, Franceschi C, Houwing-Duistermaat JJ, Slagboom PE (2014) Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum Mol Genet. 23(16):4420-32. PMID: 24688116.

  • Howey R, Cordell HJ (2014) Imputation without doing imputation: a new method for the detection of non-genotyped causal variants. Genet Epidemiol 38(3):173-90. PMID: 24535679.

  • Al Safar HS, Cordell HJ, Jafer O, Anderson D, Jamieson SE, Fakiola M, Khazanehdari K, Tay GK, Blackwell JM (2013) A genome-wide search for type 2 diabetes susceptibility genes in an extended arab family. Ann Hum Genet. 7(6):488-503. PMID: 23937595.

  • Mamasoula C, Prentice RR, Pierscionek T, Pangilinan F, Mills JL, Druschel C, Pass K, Russell MW, Hall D, Topf A, Brown DL, Zelenika D, Bentham J, Cosgrove C, Bhattacharya S, Riveron JG, Setchfield K, Brook JD, Bu'Lock FA, Thornborough C, Rahman TJ, Doza JP, Tan HL, O'Sullivan J, Stuart AG, Blue G, Winlaw D, Postma AV, Mulder BJ, Zwinderman AH, van Engelen K, Moorman AF, Rauch A, Gewillig M, Breckpot J, Devriendt K, Lathrop GM, Farrall M, Goodship JA, Cordell HJ, Brody LC, Keavney BD (2013) Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls. Circ Cardiovasc Genet. 6(4):347-53. PMID: 23876493.

  • Ayers KL, Cordell HJ (2013) Identification of grouped rare and common variants via penalized logistic regression Genet Epidemiol 7(6):592-602. PMID: 23836590.

  • Cordell HJ, Bentham J, Topf A, Zelenika D, Heath S, Mamasoula C, Cosgrove C, Blue G, Granados-Riveron J, Setchfield K, Thornborough C, Breckpot J, Soemedi R, Martin R, Rahman TJ, Hall D, van Engelen K, Moorman AF, Zwinderman AH, Barnett P, Koopmann TT, Adriaens ME, Varro A, George AL Jr, Dos Remedios C, Bishopric NH, Bezzina CR, O'Sullivan J, Gewillig M, Bu'lock FA, Winlaw D, Bhattacharya S, Devriendt K, Brook JD, Mulder BJ, Mital S, Postma AV, Lathrop GM, Farrall M, Goodship JA, Keavney BD (2013) Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. Nature Genetics 45(7):822-824. PMID: 23708191.

  • Fakiola M, Strange A, Cordell HJ, Miller EN, Pirinen M, Su Z, Mishra A, Mehrotra S, Monteiro GR, Band G, Bellenguez C, Dronov S, Edkins S, Freeman C, Giannoulatou E, Gray E, Hunt SE, Lacerda HG, Langford C, Pearson R, Pontes NN, Rai M, Singh SP, Smith L, Sousa O, Vukcevic D, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Wilson ME, Deloukas P, Peltonen L, Christiansen F, Witt C, Jeronimo SM, Sundar S, Spencer CC, Blackwell JM, Donnelly P (2013) Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nature Genetics 45(2):208-213. PMID: 23291585.

  • Cordell HJ, Topf A, Mamasoula C, Postma AV, Bentham J, Zelenika D, Heath S, Blue G, Cosgrove C, Riveron JG, Darlay R, Soemedi R, Wilson IJ, Ayers KL, Rahman TJ, Hall D, Mulder BJ, Zwinderman AH, van Engelen K, Brook JD, Setchfield K, Bu'lock FA, Thornborough C, O'Sullivan J, Stuart AG, Parsons J, Bhattacharya S, Winlaw D, Mital S, Gewillig M, Breckpot J, Devriendt K, Moorman AF, Rauch A, Lathrop GM, Keavney BD, Goodship JA (2013) Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot. Hum Molec Genet :22(7):1473-1481. PMID: 23297363.

  • Lui JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ, Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA (2012) Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis. Nature Genetics 44(10): 1137-1141.

  • Soemedi R, Wilson IJ, Bentham J, Darlay R, Topf A, Zelenika D, Cosgrove C, Setchfield K, Thornborough C, Granados-Riveron J, Blue GM, Breckpot J, Hellens S, Zwolinkski S, Glen E, Mamasoula C, Rahman TJ, Hall D, Rauch A, Devriendt K, Gewillig M, O' Sullivan J, Winlaw DS, Bu'Lock F, Brook JD, Bhattacharya S, Lathrop M, Santibanez-Koref M, Cordell HJ, Goodship JA, Keavney BD (2012) Contribution of global rare copy-number variants to the risk of sporadic congenital heart disease. American Journal of Human Genetics 91(3):489-501.

  • Howey R and Cordell HJ (2012) PREMIM and EMIM: Tools for estimation of maternal, imprinting and interaction effects using multinomial modelling. BMC Bioinformatics 13(1):149.

  • Goodship JA, Hall D, Topf A, Mamasoula C, Griffin H, Rahman TJ, Glen E, Tan H, Palomino Doza J, Relton CL, Bentham J, Bhattacharya S, Cosgrove C, Brook D, Granados-Riveron J, Bu'lock FA, O'Sullivan J, Stuart AG, Parsons J, Cordell HJ and Keavney B (2012) A Common Variant in the PTPN11 Gene Contributes to the Risk of Tetralogy of Fallot. Circ Cardiovasc Genet 5(3):287-92.

  • Ueki M and Cordell HJ (2012) Improved statistics for genome-wide interaction analysis. PLoS Genet 8(4):e1002625.

  • Soemedi R, Topf A, Wilson IJ, Darlay R, Rahman T, Glen E, Hall D, Huang N, Bentham J, Bhattacharya S, Cosgrove C, Brook JD, Granados-Riveron J, Setchfield K, Bu'lock F, Thornborough C, Devriendt K, Breckpot J, Hofbeck M, Lathrop M, Rauch A, Blue GM, Winlaw DS, Hurles M, Santibanez-Koref M, Cordell HJ, Goodship JA and Keavney BD (2012) Phenotype-specific effect of chromosome 1q21.1 rearrangements and GJA5 duplications in 2436 congenital heart disease patients and 6760 controls. Hum Mol Genet 21(7):1513-20.

  • Mells GF, Floyd JAB, Morley KI, Cordell HJ, Franklin CS, Heneghan M, Neuberger JM, Donaldson PT, Dawwas M, Day DB, Ducker SJ, Muriithi AW, Wheater EF, The UK PBC Consortium, The Wellcome Trust Case Control Consortium, Jones DE, Peltonen L, Alexander GJ, Sandford RN and Anderson CA (2011) Genome-wide association study identifies 12 additional susceptibility loci for primary biliary cirrhosis. Nature Genetics 43(4):329-32.

  • Brown SJ, Asai Y, Cordell HJ, Campbell LE, Zhao Y, Liao H, Northstone K, Henderson J, Alizadehfar R, Ben-Shoshan M, Morgan K, Roberts G, Masthoff LJ, Pasmans SG, van den Akker PC, Wijmenga C, Hourihane JO, Palmer CN, Lack G, Clarke A, Hull PR, Irvine AD and McLean WH (2011) Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol 127(3):661-7.

  • Ainsworth HF, Unwin J, Jamison DL and Cordell HJ (2011) Investigation of maternal effects, maternal-foetal interactions and parent-of-origin effects (imprinting), using mothers and their offspring. Genetic Epidemiology 35:19-45.

  • Ayers KL and Cordell HJ (2010) SNP selection in genome-wide and candidate gene studies via penalized logistic regression. Genetic Epidemiology 34:879-891.

  • Hughes AE, Orr N, Cordell HJ and Goodship T (2010) Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent: reply. Nature Genetics 42:555-556.

  • O'Regan GM, Campbell LE, Cordell HJ , Irvine AD, McLean WH, Brown SJ (2010) Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations. Journal of Allergy and Clinical Immunology 125:170-174.

  • Cordell HJ, Darlay R, Charoen P, Stewart A, Gullett AM, Lambert HJ, Malcolm S, Feather SA, Goodship TH, Woolf AS, Kenda RB, Goodship JA; UK VUR Study Group (2010) Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. J Am Soc Nephrol 21:113-123.

  • Mitchell AL, Cordell HJ,Soemedi R, Owen K, Skinningsrud B, Wolff AB, Ericksen M, Undlien D, Husebye E and Pearce SH (2009) Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility. J Clin Endocrinol Metab 94:5139-5145.

  • Brown SJ, Relton CL, Liao H, Zhao Y, Sandilands A, McLean WH, Cordell HJ and Reynolds NJ (2009) Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children. British Journal of Dermatology 161:884-889.

  • Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly M, Nelson M, John S, Holden A, Graham J, Park BK, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP and Day CP (2009) HLA B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin: genome-wide and candidate gene studies. Nature Genetics 41:816-819.

  • Croiseau P and Cordell HJ (2009) Analysis of North American Rheumatoid Arthritis Consortium data using a penalized logistic regression approach. BMC Proceedings 3 Suppl 7:S61.

  • Anand SS, Xie C, Pare G, Montpetit A, Rangarajan S, McQueen M, Cordell H, Keavney B, Yusef S, Hudson TJ and Engert JC (2009) Genetic variants associated with Myocardial Infarction risk factors in over 8,000 individuals from five ethnic groups: The INTERHEART Genetics Study. Circulation: Cardiovascular Genetics 2:16-25.

  • Cordell HJ (2009) Detecting gene-gene interactions that underlie human diseases. Nature Reviews Genetics 10:392-404.

  • Rodriguez E, Baurecht H, Herberich E, Waganpfeil S, Brown SJ, Cordell HJ, Irvine A and Weidinger S (2009) Meta analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. Journal of Allergy and Clinical Immunology 123:1361-1370.

  • Griffin HR, Hall DH, Topf A, Eden J, Stuart AG, Parsons J, Peart I, Deanfield J, O'Sullivan J, Babu-Narayan S, Gatzoulis MA, Bu'Lock FA, Bhattacharya S, Bentham J, Farrall M, Brook JD, Burn J, Cordell HJ, Goodship JA and Keavney B (2009) Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation. PLoS ONE 4:e4978.

  • Biernacka JM and Cordell HJ (2009) A composite likelihood approach for identifying polymorphisms that are potentially directly associated with disease. European Journal of Human Genetics 17:644-650.

  • Roycroft M, Fichna M, McDonald D, Owen K, Zurawek M, Gryczynska M, Januszkiewicz-Lewandowska D, Fichna P, Cordell H, Donaldson P, Nowak J, Pearce S (2008) The tryptophan 620 allele of the lympoid tyrosine phosphate (PTPN22) gene predisposes to autoimmune Addison's disease. Clinical Endocrinology 70:358-362.

  • Cordell HJ (2009) Estimation and testing of gene-environment interactions in family-based association studies. Genomics 93:5-9.

  • Jamieson SE, de Roubaix L-A, Cortina-Boja M, Tan HK, Mui EJ, Cordell HJ, Kirisits MJ, Miller EN, Peacock CS, Hargrave AC, Coyne JJ, Boyer K, Bessieres MH, Buffolano W, Ferret N, Franck J, Kieffer F, Meier P, Nowakowska DE, Paul M, Peyron F, Stray-Pedersen B, Prusa A-R, Thulliez P, Wallon M, Peterson E, McLeod R, Gilbert RE and Blackwell JM (2008) Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis. PLoS ONE 3:e2285.

  • Brown SJ, Relton CL, Liao H, Zhao Y, Sandilands A, Wilson IJ, Burn J, Reynolds NJ, McLean WH and Cordell HJ (2008) Filaggrin loss-of-function mutations and childhood atopic eczma: a population-based case-control study. Journal of Allergy and Clinical Immunology 121:940-946.

  • Brown SJ, Sandilands A, Zhao Y, Liao H, Relton CL, Meggitt SJ, Trembath RC, Barker JNWN, Reynolds NJ, Cordell HJ and McLean WH (2008) Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema. Journal of Investigative Dermatology 128:1591-1594.

  • Wheeler E and Cordell HJ (2007) Quantitative trait association in parent offspring trios: extension of case/pseudocontrol method and comparison of prospective and retrospective approaches. Genetic Epidemiology 31:813-833.

  • Charoen P, Biernacka JM and Cordell HJ (2007) Linkage and association analysis of GAW15 simulated data: fine-mapping of chromosome 6 region. BMC Proceedings 1(Suppl1):S23.

  • Biernacka JM, Charoen P and Cordell HJ (2007) Joint linkage and association analysis for identification of potentially causal polymorphisms in GAW15 data. BMC Proceedings 1(Suppl1):S36.

  • Biernacka JM and Cordell HJ (2007) Exploring causality via identification of SNPs or haplotypes responsible for a linkage signal. Genetic Epidemiology 31:727-740.

  • Sutherland A, Davies J, Owen CJ, Vaikkakara, Walker C, Cheetham TD, James RA, Perros P, Donaldson PT, Cordell HJ, Quinton R and Pearce S (2007) Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves disease susceptibility. Journal of Clinical Endocrinology and Metabolism 92:3338-3341.

  • Croiseau P, Genin E and Cordell HJ (2007) Dealing with missing data in family-based association studies: a multiple imputation approach. Human Heredity 63:229-238.

  • Imrie H, Freel M, Mayosi BM, Davies E, Fraser R, Ingram M, Cordell HJ, Farrall M, Avery PJ, Watkins H, Keavney B and Connell JMC (2006) Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene. The Journal of Clinical Endocrinology & Metabolism 91: 5051-5056.

  • Biernacka JM and Cordell HJ (2006) Perils and pitfalls of permutation tests for distinguishing the effects of neighbouring polymorphisms. Genetic Epidemiology 30:582-589.

  • Cordell HJ (2006) Estimation and testing of genotype and haplotype effects in case/control studies: comparison of weighted regression and multiple imputation procedures. Genetic Epidemiology 30:259-275.

  • Barber MJ, Todd JA and Cordell HJ (2006) A multimarker regression-based test of linkage for affected sib-pairs at two linked loci. Genetic Epidemiology 30:191-208.

  • Barber MJ, Wheeler E and Cordell HJ (2006) Linkage analysis of GAW14 simulated data: comparison of multimarker, multipoint and conditional approaches. BMC Genetics 6 (Suppl 1): S40

  • Wheeler E, Miller EN, Peacock CS, Donaldson IJ, Shaw M-A, Jamieson SE, Blackwell JM and Cordell HJ (2006) Genome-wide scan for loci influencing quantitative immune response traits in the Belem Family Study: comparison of methods and summary of results. Annals of Human Genetics 70: 78-97.

  • Cordell HJ and Clayton DG (2005) Genetic Association Studies. The Lancet 366:1121-1131.

  • Howson JMM, Barratt BJ, Todd JA and Cordell HJ (2005) Comparison of population and family-based methods for genetic association analysis in the presence of interacting loci. Genetic Epidemiology 29:51-67.

  • Cordell HJ (2004) Bias towards the null hypothesis in model-free linkage analysis is highly dependent on the test statistic used. American Journal of Human Genetics 74:1294-1302.

  • Cordell HJ (2004) Properties of case/pseudocontrol analysis for genetic association studies: effects of recombination, ascertainment and multiple affected offspring. Genetic Epidemiology 26:186-205.

  • Cordell HJ, Barratt BJ and Clayton DG (2004) Case/pseudocontrol analysis in genetic association studies: a unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions and parent-of-origin effects. Genetic Epidemiology 26:167-185.

  • Ueda H, Howson JMM, Esposito L , Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KMD, Smith A, DiGenova G, Herr MH, Dahlman I, Payne F, Smyth D , Lowe C, Twells RCJ, Howlett S, Healy B, Smink LJ, Lam ACH, Cordell HJ, Walker NM, Bordin C, Hulme H, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 23:506-511

  • Cordell HJ (2003) Affected-sib-pair data can be used to distinguish two-locus heterogeneity from two-locus epistasis. American Journal of Human Genetics 73:1468-1471.

  • Cordell HJ and Clayton DG (2002) A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. American Journal of Human Genetics 70: 124-141.

  • Cordell HJ (2002) Epistasis - what it means, what it doesn't mean, statistical methods to detect it in humans. Human Molecular Genetics 11: 2463-2468.

  • Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA. (2001) Haplotype tagging for the identification of common disease genes. Nature Genetics 29: 233-237.

  • Cordell HJ (2001) Sample size requirements to control for stochastic variation in magnitude and location of allele-sharing linkage statistics in affected sibling pairs. Annals of Human Genetics 65: 491-502.

  • Cordell HJ, Todd JA, Hill NJ, Lord CJ, Lyons PA, Peterson LB, Wicker LS and Clayton DG (2001) Statistical modelling of inter-locus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes. Genetics 158: 357-367.

  • Koeleman BPC, Dudbridge F, Cordell HJ and Todd JA (2000) Adaptation of the extended transmission /disequilibrium test for distinguishing associations of multiple loci: the conditional extended transmission /disequilibrium test. Annals of Human Genetics 64: 207-213.

  • Cordell HJ and Olson JM (2000) Correcting for ascertainment bias of relative risk estimates obtained using affected-sib-pair linkage data. Genetic Epidemiology 18: 307-321.

  • Cordell HJ, Wedig GC, Jacobs KB and Elston RC (2000) Multilocus linkage tests based on affected relative pairs. American Journal of Human Genetics 66: 1273-1286.

  • Olson JM and Cordell HJ (2000) Ascertainment bias in the estimation of sibling genetic risk parameters. Genetic Epidemiology 18: 217-235.

  • Cordell HJ and Carpenter JR (2000) Bootstrap confidence intervals for relative risk parameters in affected-sib-pair data. Genetic Epidemiology 18: 157-172.

  • Cordell HJ and Elston RC (1999) Fieller's theorem and linkage disequilibrium mapping. Genetic Epidemiology 17: 237-252.

  • Cordell HJ, Todd JA and Lathrop GM (1998) Mapping multiple linked quantitative trait loci in non-obese diabetic mice using a stepwise regression strategy. Genet Res 71:51-64.

  • Cordell HJ and Olson JM (1997) Confidence intervals for relative risk estimates from affected-sib-pair data. Genetic Epidemiology 14: 593-598.

  • Cordell HJ,Kawaguchi Y, Todd JA and Farrall M (1995) An extension of the Maximum Lod Score method to X-linked loci. Annals of Human Genetics 59:435-449.

  • Cordell HJ, Todd JA, Bennett ST, Kawaguchi Y and Farrall M (1995) Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. American Journal of Human Genetics 57: 920-934.

  • Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC and Todd JA (1994) A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371: 130-136.