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Journal
Publications |
Zirconium-Mediated Synthesis of a New
Class of 1,4-Bis(diphenylphosphino)-1,3-butadiene-Bridged Diphosphine,
NUPHOS: Highly Efficient Catalysts for Palladium-Mediated Cross
Couplings.
Julian G. Knight, Simon Doherty, Edward G.
Robins, Tom H. Scanlan, Paul A. Champkin, and William Clegg, J. Am.
Chem. Soc., 2001, 123, 5110. |
Abstract: A new class of
1,4-bis(diphenylphosphino)-1,3-butadiene bridged diphosphine (NUPHOS)
forms highly active catalysts for palladium mediated cross couplings.
The diphosphine
1,4-bis(diphenylphosphino)-1,2,3,4-tetraphenyl-1,3-butadiene (1,2,3,4-Ph4-NUPHOS),
has been prepared by the reductive coupling of diphenylacetylene with
Negishi’s reagent, followed by transmetallation of the resulting
zirconacyclopentadiene with CuCl prior to quenching with
diphenylchlorophosphine. Palladium complexes of these new diphosphines
are highly active for the cross coupling of bromobenzene and sec-butylmagnesium
bromide. In fact, catalysts based on 1,2,3,4-Ph4-NUPHOS are
approx. thirty times more active than the most active catalyst reported
to date for this coupling. |
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