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Journal
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Enantiospecific Formation of 3,6-Dihydro-1H-pyridin-2-ones:
Low Pressure Palladium-Catalysed Decarboxylative Carbonylation of
3-Tosyl-5-vinyloxazolidin-2-ones.
Julian G. Knight, Iain M. Lawson and
Christopher N. Johnson, Synthesis,
2006,
227. |
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Abstract:
Palladium-catalysed decarboxylative carbonylation of
3-tosyl-5-vinyloxazolidin-2-ones 5 occurs at atmospheric pressure
to give 1-tosyl-3,6-dihydro-1H-pyridin-2-ones 6. The
reaction proceeds with no loss of enantiopurity and detosylation with
sodium naphthalenide gives the title compounds in good yields. |
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