Abstracts

Monday, 07 February 2011

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Journal Publications

Synthesis of highly substituted pyrrolidines via palladium catalyzed formal [2+3] cycloaddition of 5-vinyloxazolidin-2-ones to activated alkenes.  

Julian G. Knight, Kirill Tchabanenko, Paul A. Stoker and Simon J. Harwood, Tetrahedron Lett., 2005, 46, 6261.

Abstract: Glycine-derived N-tosyl-5,5-divinyloxazolidin-2-one undergoes a palladium catalysed decarboxylative ring-opening cyclization with strongly electron deficient alkylidenemalonate derivatives to give highly substituted pyrrolidines containing two contiguous quaternary centres.

 
 

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