1 Introduction

Do you desperately want to perform a case/control analysis but only have pedigree data? If each pedigree contains a case with parents then one option is to take the cases and create pseudocontrols using the non-transmitted alleles from the parents. The case/control analysis of interest can then be performed using the case/pseudocontrol data set. Unfortunately, creating the pseudocontrols can be a hassle, especially if the pedigree data does not consist of only case/parent trios. However, it is no longer a hassle as PseudoCons is here to help! Simply run PseudoCons on your pedigree data set to create a case/pseudocontrol data set.

Some theory behind case/pseudocontrol analysis can be found in the work by Cordell (2004) and Cordell et al. (2004).