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Publications

• Manville, C.M., Smith, K., Sondka, Z., Rance, H., Cockell, S., Cowell, I.G., Lee, K.C., Morris, N.J., Padget, K., Jackson, G.H., Austin, C.A. Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells. Biol. Open 2015 bio.014308. doi:10.1242/bio.014308
• Ben-David, U., Cowell, I.G., Austin, C.A., Benvenisty, N. Brief Reports: Controlling the Survival of Human Pluripotent Stem Cells by Small Molecule-Based Targeting of Topoisomerase II alpha. Stem Cells 2015 33, 1013–1019
• Best, A., James, K., Dalgliesh, C., Hong, E., Kheirolahi-Kouhestani, M., Curk, T., Xu, Y., Danilenko, M., Hussain, R., Keavney, B., Wipat, A., Klinck, R., Cowell, I.G., Cheong Lee, K., Austin, C.A., Venables, J.P., Chabot, B., Santibanez Koref, M., Tyson-Capper, A., Elliott, D.J. Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. Nat. Commun. 2014 5. doi:10.1038/ncomms5760
• Smith, K.A., Cowell, I.G., Zhang, Y., Sondka, Z., Austin, C.A. The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. Genes. Chromosomes Cancer 2013 53, 117–128. doi:10.1002/gcc.22124
• Lee K.C., Padget K., Curtis H., Cowell I. G., Moiani D., Sondka Z., Morris N..J, Jackson G.H., Cockell S.J., Tainer J.A., Austin C.A. MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open. 2012 1:863-73. doi: 10.1242/bio.20121834.
• Cowell IG, Austin CA. Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia?. Cell Cycle 2012, 11(17), 3143-3144.
• Cowell IG, Austin CA. Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents. International Journal of Environmental Research and Public Health 2012, 9(6), 2075-2091.
• Cowell IG, Sondka Z, Smith K, Lee KC, Manville CM, Sidorczuk-Lesthuruge M, Rance HA, Padget K, Jackson GH, Adachi N, Austin CA. Model for MLL translocations in therapy-related leukemia involving topoisomerase II beta-mediated DNA strand breaks and gene proximity. Proceedings of the National Academy of Sciences 2012, 109(23), 8989-8994.
• Cowell IG, Tilby MJ, Austin CA. An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. Mutagenesis 2011, 26(2), 253-260.
• Cowell IG, Papageorgiou N, Padget K, Watters GP, Austin CA. Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. Nucleus 2011, 2(1), 61-71.
• Willmore E, Elliott SL, Mainou-Fowler T, Summerfield GP, Jackson GH, O'Neill F, Lowe C, Carter A, Harris R, Pettitt AR, Cano-Soumillac C, Griffin RJ, Cowell IG, Austin CA, Durkacz BW. DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clinical Cancer Research 2008, 14(12), 3984-3992.
• Toyoda E, Kagaya S, Cowell IG, Kurosawa A, Kamoshita K, Nishikawa K, Iiizumi S, Koyama H, Austin CA, Adachi N. NK₃₁₄, a topoisomerase II inhibitor that specifically targets the alpha isoform. Journal of Biological Chemistry 2008, 283(35), 23711-23720.
• Leontiou C, Watters GP, Gilroy KL, Heslop P, Cowell IG, Craig K, Lightowlers RN, Lakey JH, Austin CA. Differential selection of acridine resistance mutations in human DNA topoisomerase II beta is dependent on the acridine structure. Molecular Pharmacology 2007, 71(4), 1006-1014.
• Cowell I, Sunter NJ, Singh PB, Austin CA, Durkacz BW, Tilby MJ. γH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS ONE 2007, 2(10), e1057.
• Zhao Y, Thomas HD, Batey M, Cowell I, Richardson C, Griffin RJ, Calvert AH, Newell DR, Smith G, Curtin NJ. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Research 2006, 66(10), 5354-5362.
• Cowell, I.G., Durkacz, B.W., Tilby, M.J. Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated. Biochemical Pharmacology 2005, 71(1-2), 13-20.
• Brown JP, Singh PB, Cowell IG. Composite cis-acting epigenetic switches in eukaryotes: lessons from Drosophila Fab-7 for the Igf2-H19 imprinted domain. Genetica 2003, 117(2/3), 199-207.
• Cowell IG. E4BP4/NFIL3, a PAR-related bZIP factor with many roles. BioEssays 2002, 24(11), 1023-1029.
• Cowell IG, Aucott R, Mahadevaiah SK, Burgoyne PS, Huskisson NS, Bongiorni S, Prantera G, Fanti L, Pimpinelli S, Wu R, Gilbert D, Shi W, Fundele R, Morrison H, Jeppesen P, Singh PB. Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma 2002, 111(1), 22-36.
• Filesi I, Cardinale A, van der Sar S, Cowell IG, Singh PB, Biocca S. Loss of Heterochromatin Protein 1 (HP1) chromodomain function in mammalian cells by intracellular antibodies causes cell death. Journal of Cell Science 2002, 115(9), 1803-1813.
• Scholzen T, Endl E, Wohlenberg C, Sar SvanDer, Cowell IG, Gerdes J, Singh PB. The Ki-67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher-order chromatin structure. Journal of Pathology 2002, 196(2), 135-144.
• Jones DO, Mattei MG, Horsley D, Cowell IG, Singh PB. The gene and pseudogenes of Cbx3/mHP1 gamma. DNA sequence 2001, 12(3), 147-160.
• Wang G, Ma A, Chow CM, Horsley D, Brown NR, Cowell IG, Singh PB. Conservation of heterochromatin protein 1 function. Molecular & Cellular Biology 2000, 20(18), 6970-6983.
• Kourmouli N, Theodoropoulos PA, Dialynas G, Bakou A, Politou AS, Cowell IG, Singh PB, Georgatos SD. Dynamic associations of heterochromatin protein 1 with the nuclear envelope. The EMBO Journal 2000, 19(23), 6558-6568.
• Jones DO, Cowell IG, Singh PB. Mammalian chromodomain proteins: their role in genome organisation and expression. BioEssays 2000, 22(2), 124-137.
• Cowell IG, Willmore E, Chalton DA, Marsh KL, Jazrawi E, Fisher LM, Austin CA. Nuclear distribution of human DNA topoisomerase IIβ: A nuclear targeting signal resides in the 116-residue C-terminal tail. Experimental Cell Research 1998, 243(2), 232-240.
• Cowell IG, Austin CA. Self-association of chromo domain peptides. Biochimica et Biophysica Acta: Protein Structure and Molecular Enzymology 1997, 1337(2), 198-206.
• Cowell IG, Hurst HC. Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. Nucleic Acids Research 1996, 24(18), 3607-3613.
• Cowell IG. Repression versus activation in the control of gene transcription. Trends in Biochemical Sciences 1994, 19(1), 38-42.
• Cowell IG, Hurst HC. Transcriptional repression by the human bZIP factor E4BP4: Definition of a minimal repression domain. Nucleic Acids Research 1994, 22(1), 59-65.
• Spencer SR, Taylor JB, Cowell IG, Xia CL, Pemble SE, Ketterer B. The human mitochondrial NADH: Ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase p1-1 gene on chromosome 11q13. Genomics 1992, 14(4), 1116-1118.
• Xia CL, Cowell IG, Dixon KH, Pemble SE, Ketterer B, Taylor JB. Glutathione transferase pi its minimal promoter and downstream cis- acting element. Biochemical and Biophysical Research Communications 1991, 176(1), 233-240.
• Dixon KH, Cowell IG, Xia CL, Pemble SE, Ketterer B, Taylor JB. Control of expression of the human glutathione S-transferase Pi gene differs from its rat homologue. Biochemical and Biophysical Research Communications 1989, 163(2), 815-822.
• Cowell IG, Dixon KH, Pemble SE, Ketterer B, Taylor JB. The structure of the human glutathione-Pi gene. Biochemical Journal 1988, 255(1), 79-83.
• Taylor JB, Pemble SE, Cowell IG, Dixon KH, Ketterer B. Molecular biology of the glutathione transferases. Biochemical Society Transactions 1986, 15, 578-579.