Our lab has really enjoyed this year’s meetings

Big thank you to all the organisers!

Gordon Research Conference. The Role of Cell Polarity Networks in Development, Growth Control, and Regeneration

Ulrich Tepass & Jeremy F. Nance

EMBO Workshop. C. elegans development, cell biology and gene expression

Sander van den Heuvel, Sophie Jarriault & Alex Hajnal

Jack really enjoyed presenting his poster on: “Revisiting how microtubules induce cell polarity in the C.elegans zygote” WELL DONE!

FSER meeting in Les Treilles on Cell Polarity and Morphogenesis

André Le Bivic & Daniel St Johnston

UK C. elegans meeting

Patricija van Oosten-Hawle, Netta Cohen, Ron Chen & Ian Hope

Alicia did a great job presenting her poster on: “Crosstalk between PAR proteins and the actomyosin cytoskeleton in zygote polarity”

Institute for Cell and Molecular Biosciences Away Day

Alicia won a poster prize! WELL DONE!!

Congratulations all for such a nice paper!

Morphogenetic degeneracies in the actomyosin cortex

Naganathan et al., (2018)

Abstract. One of the great challenges in biology is to understand the mechanism by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-scale flows emerge from the collective action of actomyosin filaments and actin binding proteins (ABPs). Large-scale flow dynamics can be captured by active gel theory by considering force balances and conservation laws in the actomyosin cortex. However, which molecular activities contribute to flow dynamics and large-scale physical properties such as viscosity and active torque is largely unknown. By performing a candidate RNAi screen of ABPs and actomyosin regulators we demonstrate that perturbing distinct molecular processes can lead to similar flow phenotypes. This is indicative for a ’morphogenetic degeneracy’ where multiple molecular processes contribute to the same large-scale physical property. We speculate that morphogenetic degeneracies contribute to the robustness of bulk biological matter in development.