Limbal stem cells (LSCs) play a vital role in corneal epithelial maintenance, cell renewal, and wound healing. Limbal stem cell deficiency (LSCD) poses a threat to vision, motivating innovative therapies such as ex-vivo cultured transplants. Our work aims to investigate the efficacy of LSC transplants for treating LSCD through computational and mathematical modelling. 

In this project we are working with leading consultant ophthalmologist Professor Francisco Figueiredo, a pioneer of limbal stem cell transplant therapies, and Professor Majlinda Lako, expert stem cell scientist, to develop mathematical tools to assist in the diagnosis of LSCD. Through sophisticated image analysis techniques, we aim to identify resilient indicators of corneal epithelial health, and success of transplant intervention.

These investigations will assist in the development of computational diagnostic tools for the monitoring of LSCD, and advance agent-based computational models of corneal wound healing. This research enhances our understanding of LSC transplant outcomes and lays the foundation for improved diagnostics and monitoring strategies for LSCD patients. 

Research team: Dr Laura Wadkin (Supervisor), Professor Anvar Shukurov (Supervisor), Dr Irina Makarenko, Professor Majlinda Lako and Professor Francisco Figueiredo.

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