HEA EDI conference

I was pleased to present my work with undergraduate summer project student Ramita Dhanda at the Higher Education Academy EDI Conference this week! Through our literature review we found a large gap in research examining the lived experiences of women in mathematics in UK Higher Education. Next step – fill this gap with our own study at Newcastle!

Paper published: mathematical modelling of OCT4 in human pluripotent stem cells

Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in PLoS ONE.

A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells

We use fractional Brownian motion and the stochastic logistic equation to describe the temporal properties of OCT4 in a growing hESC colony. We particularly look at using a time-dependent carrying capacity or an Allee effect to capture the decline in OCT4 upon cell differentiation, pictured below!

Paper published: dynamics of OCT4 in hPSCs

Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in IOP Physical Biology:

OCT4 expression in human embryonic stem cells: spatio-temporal dynamics and fate transitions

We use time-lapse experimental data of OCT4-mCherry fluorescence intensity to quantify the temporal and spatial dynamics of the pluripotency transcription factor OCT4 in a growing hESC colony in the presence and absence of BMP4.

Take AIM awards

Last year I won 2nd Prize in the Smith Institute’s TakeAIM competition (Articulating the Influence of Mathematics). The competition is an opportunity for university students to showcase their work on the industrial stage and to highlight the crucial role mathematics plays in solving real-world problems while rewarding the academic exploration of future innovators who undertake pioneering research.

The awards ceremony at Imperial College London featured presentations from other winning entries, interesting industrial talks and a very fancy afternoon tea! My winning entry can be viewed here and the article in the school news here.

Research Associate in Mathematical Biology