Paper published: mathematical modelling of OCT4 in human pluripotent stem cells

Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in PLoS ONE.

A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells

We use fractional Brownian motion and the stochastic logistic equation to describe the temporal properties of OCT4 in a growing hESC colony. We particularly look at using a time-dependent carrying capacity or an Allee effect to capture the decline in OCT4 upon cell differentiation, pictured below!