Paper published: mathematical modelling of OCT4 in human pluripotent stem cells

Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in PLoS ONE.

A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells

We use fractional Brownian motion and the stochastic logistic equation to describe the temporal properties of OCT4 in a growing hESC colony. We particularly look at using a time-dependent carrying capacity or an Allee effect to capture the decline in OCT4 upon cell differentiation, pictured below!

Society for Mathematical Biology 2021: Modelling the spread of tree disease through forests

Enjoyed presenting my work at SMB2021 this week! Always a great conference with a wide variety of mathematical biologists. I talked about our agent-based model for the local spread of tree disease and the impact the choice of pathogen kernel has on the subsequent epidemic.