Our recent work investigating the dynamics of the pluripotency transcription factor OCT4 has been published in PLoS ONE.
We use fractional Brownian motion and the stochastic logistic equation to describe the temporal properties of OCT4 in a growing hESC colony. We particularly look at using a time-dependent carrying capacity or an Allee effect to capture the decline in OCT4 upon cell differentiation, pictured below!
