OUT NOW: Language Evolution special issue in Current Opinion in Behavioral Sciences. Read the Editorial Overview.
31 contributions from world leading authorities and upcoming bright stars on language evolution rooted in core principles on neural systems and cognition aim to provide thought provoking perspectives and new insights on the evolution of cognition and language. Articles can be found here.
Leverhulme Doctoral Training at the Instutute: Fully funded 4-year PhD studentships in behaviour informatics and the multimodal study of behaviour
BBC Radio 3 Public Engagement Activity at Sage (2017): Hear the live BBC Radio 3 broadcast with Tom Service and hear the outcome of our music and time perception experiment: How does music warp people’s perception of time?
Recent Publications and Summary:
- Mitchell AS, Thiele A, Petkov CI, Roberts A, Robbins TW, Schultz W & Lemon R (2018) Continued need for non-human primate neuroscience research. Current Biology, 28, R1186-87.
Ethically conducted work with non-human primates remains indispensable for testing and translating neural principles from rodents to primates to humans, which time and time again has led to advances in understanding the human brain and the diagnosis, prognosis and treatment of brain disorders. “We believe that in the coming period some increase in NHP studies in carefully targeted areas of neuroscience will still be needed. To ban useful primate disease models would be an extremely dangerous step to take, given the urgent need to find treatments for people suffering from these conditions.” Want to read more… Lemon (2018) Psychology Review
- Milham M and co-authors (in press) An open resource for non-human primate imaging. Neuron
First primate MRI data sharing initiative, to complement similar data sharing initiatives on child and adult human MRI. Tremendous effort and contributions from Newcastle as well as many international sites.
- Petkov CI & Marslen-Wilson W (2018) The evolution of language as a neurobiological system. Current Opinion in Behavioral Sciences: Special Issue Editorial Overview.
Thirty one contributions from world leading authorities and upcoming bright stars on language evolution rooted in core principles on neural systems and cognition. The thought provoking perspectives provide insights on the evolution of human cognition and language. Articles can be found here.
- Kikuchi Y, Sedley W, Griffiths TD & Petkov CI (2018) Evolutionarily conserved neural signatures involved in sequencing predictions and their relevance to language. Current Opinion in Behavioral Sciences
This paper synthesizes recent scientific findings to better understand how the human language system specialized and why and how it relies on evolutionarily conserved neural systems. We observe that the neural system supporting language is integrated within an ancestral system, with both systems overlapping to some extent whenever the brain needs to establish relationships (build mental structures) between events separated in time. We do this all the time when we comprehend which words relate to which other ones in a sentence, and we also do this when we realize that certain environmental events predict what will occur in the future.
- Oya H, Gander PE, Petkov CI, Adolphs R, Nourski KV, Kawasaki H, Howard MA & Griffiths TD (2018) Neural phase locking predicts BOLD response in human auditory cortex. NeuroImage
This article shows that the neuroimaging signal that is commonly used to study human brain function is related to intriguing and somewhat unexpected neural responses in the brain. This work is based on our collaboration with neursurgery groups at the University of Iowa.
- Cope TE, Wilson B, Robson H, Drinkall R, Dean L, Grube M, Jones PS, Patterson K, Griffiths TD, Rowe JB & Petkov CI. (2017) Artificial grammar learning in vascular and progressive non-fluent aphasias. Neuropsychologia, 104, 201-213.
This original paper shows that patients with two types of pathology affecting their language abilities are also affected in structuring their sensory world. This paper resulted form a collaboration with our neurology colleagues in Newcastle, Cambridge and Reading Universities.
- Milne A, Petkov CI & Wilson B (2017) Auditory and visual sequence learning in humans and monkeys using an artificial grammar learning paradigm. Neuroscience
The auditory cognitive abilities of monkeys have been suggested to differ from those in humans. This work shows that human and monkey behavior is remarkably similar for auditory or visual sequences generated by an artificial grammar initially designed to test preverbal infants. There were quantitative differences between the species which are informative but the results across the sensory modalities suggest that the sensory systems use very similar mechanisms to evaluate the structure of sounds or pictures.
- Kikuchi Y, Attaheri A, Wilson B, Rhone AE, Nourski KV, Gander PE, Kovach CK, Kawasaki H, Griffiths TD, Howard MA & Petkov CI. (2017) Sequence learning modulates neural responses and oscillatory coupling in human and monkey auditory cortex. PLoS Biology
Important comparison of intracranial recordings in humans and monkeys showing that neural rhythms (oscillations) processing speech sounds and structured sequences are remarkably similar in human and monkey auditory cortex. This points to speech segmentation in auditory cortex using evolutionarily conserved neural mechanisms. The paper also shows the importance of the work in monkeys by directly linking the effects seen in humans to a more complete understanding of relationships between brain rhythms and oscillations and populations of single neurons. These insights and analysis of the neuronal responses to the learned sequences identify different neural populations that were and can be missed with brain functional imaging techniques. This paper is also based on our collaboration with neurosurgery clinical groups at the University of Iowa, USA.
- Rinne T, Muers R, Salo E, Slater H & Petkov CI. (2017) Functional imaging of audio-visual selective attention in monkeys and humans: How do lapses in monkey performance affect cross-species correspondences? Cerebral Cortex
This original paper shows that what initially might seem as species differences in how auditory attention influences the brain may in fact be lapses in attention that play havoc with the functional imaging paper. This challenging but important project was only possible in collaboration with scientists in Finland who conducted the comparative human neuroimaging experiments and were involved in the comparative work in Newcastle.
- Poirier C, Baumann S, Joly O, Hunter D, Belazeau F, Sun L, Rees A, Petkov CI, Thiele A, Griffiths TD. (2017) Auditory motion specific mechanisms in the monkey brain. PLoS Biology
This original paper uses functional imaging to identify motion specific mechanisms in the primate brain. Typically such information can only be gleaned with neuronal recording studies but the paper shows the power of functional imaging, which, although requiring validation at a fundamental neural level, generates important insights in the specific brain areas involved in this case the perception of movement in our environment.
- Hiroyuki O, Howard MA, Magnotta VA, Kruger A, Griffiths TD, Lemieux L, Carmichael DW, Petkov CI, Kawasaki H, Kovach CK, Sutterer MJ, Adolphs R (2017) Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI. Journal of Neuroscience Methods, 277: 101-112.
Crucial development and safety testing of a novel approach for mapping directed neural connectivity in the human brain. This development was made possible by the prior work in nonhuman animals, which can now be conducted in humans as this paper shows and is relevant for understanding the impact of deep brain stimulation that is prominently in use to treat patients suffering from movement or other disorders. This paper is based on our collaboration with the neursurgery group at the University of Iowa, USA.
- Wilson B, Marslen-Wilson W & Petkov CI (2017) Conserved sequence processing in primate frontal cortex. Trends in Neurosciences 40(2): 72-82.
This paper synthesizes behavioral and neuroimaging data in human and nonhuman animals pointing to subregions of the frontal cortex that have corresponding functions. These regions are adjacent to ones that are crucial for language. A heuristic model is proposed of how and which language operations may be emulated by ‘structured sequence learning’ tasks and subserved by corresponding neural systems.
- See other papers by way of the publications tab above…
Our group is pursuing evolutionary relationships in brain function. We are guided by the notion that information on how the human brain changed during its evolutionary history will be indispensable for advancing treatments for cognitive and communication disorders. This includes addressing forms of aphasia, agnosia and language disorders.
Our research uses advanced imaging and neurophysiological methods to study perceptual awareness and cognition, with an emphasis on communication: auditory or multisensory. Research Directions
As you can see, we work with typical individuals and patients whenever the scientific questions can be answered in humans. We also collaborate with neurosurgery groups working with patients being treated for brain disorders. However, whenever necessary and the scientific questions cannot be addressed in humans alone, we also work to understand how the brain works, why neural systems falter and what we might be able to do to improve learning and brain plasticity to compensate for impairments in nonhuman animals. For instance, we conduct comparative studies to test for and establish direct relationships to the work in humans, making the animal research as relevant for human medical science as is possible. Our laboratory follows the highest ethical standards for all of our human and nonhuman animal work and all of the work is stricly regulated by local, national and international regulatory bodies. Furthemore, our laboratory is firmly rooted in the principle that scientific discovery can and should co-occur with advances in welfare (human or nonhuman). To this aim we actively contribute towards advancing the 3Rs principles.
For further information see Newcastle University’s statement and information on animal research: here.
Alexander von Humboldt Foundation
National Institutes of Health