We are recruiting 3 postdoc positions in structural biology and structure-based drug discovery
Early-to-mid career postdocs very welcome. Deadline 13 December
Research associate in rare disease drug discovery – (job ID: 11461) You will drive a structure-based drug discovery project in an academic setting, funded by LifeArc and Action Medical Research, working closely with medicinal chemists in Oxford and clinical scientists in UCL towards hit-to-lead inhibitor optimisation for a rare epileptic disorder. (Skills: crystallography, SPR, activity assays, CETSA; bit of cryo-EM)
Research associate in structure based design of cyclic peptides – (job ID: 11462) You will run an academic-industrial collaboration with Bicycle Therapeutics, towards structural and biophysical characterisation of bicyclic peptides in complex with novel therapeutic targets in immune-metabolism/oncology. (Skills: different expression approaches, crystallography, SPR; bit of cryo-EM)
Research associate in structure-based AI-assisted hit finding – (job ID: 13927) You will lead an early-stage discovery project funded by a patient foundation, towards small molecule therapy for Friedreich’s ataxia targeting a multi-protein complex. You will work closely with an AI company in hit finding, and run validation studies to guide compound design through machine learning (Skills: ITC, SPR, cryo-EM & x-ray, activity assays).