Dr. James C Knight
I am a lecturer in radiochemistry in the School of Natural and Environmental Sciences at Newcastle University. My research focusses on the synthesis and preclinical evaluation of radiopharmaceuticals for imaging and therapeutic applications.
I am the Head of Admissions for MSc Chemistry and Drug Chemistry programmes and the lead for radiochemistry within the Discovery of Medicines research theme in the Faculty of Medical Sciences. I was previously the Degree Programme Director for MSc Drug Chemistry.
I have authored 85 publications (with >1500 citations) in this area and have co-authored 2 textbooks on click chemistry and its role in radiochemistry. I also sit on the editorial board of several peer-reviewed journals.
My research has been generously supported by Bone Cancer Research Trust, EPSRC, Orthopaedic Research UK, UK SPINE, Wellcome Trust, and NIHR.
Latest Publications
83. Toni A. Pringle and James C. Knight*. The Effects of Buffer, pH, and Temperature Upon SPAAC Reaction Rates. Organic and Biomolecular Chemistry, 2025, in press.
82. Toni A. Pringle, Erik-Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight*, Saimir Luli*. Synthesis and Preclinical Evaluation of a 89Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury. Scientific Reports, 2024, 14, 633.
81. Stavros Melemenidis, James C. Knight, Veerle Kersemans, Francisco Perez-Balderas, Niloufar Zarghami, Manuel Sarmiento Soto, Bart Cornelissen, Ruth J. Muschel, and Nicola R. Sibson*. 2024. In Vivo PET Detection of Lung Micrometastasis in Mice by Targeting Endothelial VCAM-1 Using a Dual-Contrast PET/MRI Probe. International Journal of Molecular Sciences, 2024, 25(13), 7160, 1-19.
80. Lydia Cooke, Katie Gristwood, Kate Adamson, Mark Sims, Michael Deary, Dawn Bruce, Antony Antoniou, Hannah Walden, James C. Knight, Timothé Antoine-Brunet, Marie Joly, David Goyard, Pierre-Henri Lanoë, Nathalie Berthet, Valery Kozhevnikov*. Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Strain Alkynes. Dalton Transactions, 2024, 53(37), 15501
79. Tracey Luu, Katie Gristwood, James C. Knight*, and Manuela Jörg*. Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications. Bioconjugate Chemistry, 2024, 35(6), 715-731. doi.org/10.1021/acs.bioconjchem.4c00084
78. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. Synthesis and in vitro evaluation of a HER2-specific immunoSCIFI probe. ACS Omega, 2023, 8, 50, 47905-47912. (journal cover).
77. Toni A. Pringle, Oliver Coleman, Akane Kawamura, James C. Knight*. The Influence of Degree of Labelling upon Cellular Internalisation of Antibody-Cell Penetrating Peptide Conjugates. RSC Advances, 2022, 12, 27716-27722.
76. Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen Blair, Kenneth S. Rankin*, James C. Knight*. Synthesis and In Vivo Evaluation of a Site-Specifically Labelled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Bioconjugate Chemistry, 2022, 33(8), 1564-1573. (journal cover).
75. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. In situ excitation of BODIPY fluorophores by Cerenkov Luminescence. Chem. Commun., 2022, 58, 11689-11692.
