Publications
54. Toni A. Pringle, Erik-Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight*, Saimir Luli*. Synthesis and Preclinical Evaluation of a 89Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury. Scientific Reports, 2024, 14, 633.
53. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. Synthesis and in vitro evaluation of a HER2-specific immunoSCIFI probe. ACS Omega, 2023, 8, 50, 47905-47912 (journal cover).
52. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. In situ excitation of BODIPY fluorophores by Cerenkov Luminescence. Chem. Commun., 2022, 58, 11689-11692.
51. Toni A. Pringle, Oliver Coleman, Akane Kawamura, James C. Knight*. The Influence of Degree of Labelling upon Cellular Internalisation of Antibody-Cell Penetrating Peptide Conjugates. RSC Advances, 2022, 12, 27716-27722.
50. Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen Blair, Kenneth S. Rankin*, James C. Knight*. Synthesis and In Vivo Evaluation of a Site-Specifically Labelled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Bioconjugate Chemistry, 2022, 33(8), 1564-1573. (journal cover).
49. Corey D. Chan, Marcus J. Brookes, Riya Tanwani, Chloe Hope, Toni A. Pringle, James C. Knight, Kenneth S. Rankin. Investigating the Mechanisms of Indocyanine Green (ICG) Cellular Uptake in Sarcoma. BioRxiv (2021). Preprint at https://www.biorxiv.org/content/10.1101/2021.04.05.438013v1
48. Sophie Poty, Kormal Mandeylwala, Edward O’Neill, James C. Knight, Bart Cornelissen, and Jason Lewis. 89Zr-PET imaging of DNA double-strand breaks for the early monitoring of response following α- and β-particle radioimmunotherapy in a mouse model of pancreatic ductal adenocarcinoma. Theranostics, 2020, 10(13), 5802-5814. (journal cover).
47. B. C. Baljer, S. Kolhe, C. D. Chan, F. Nicoli, A. Ghanbasha, M. J. Brookes, Z. Gamie, K. M. Ghosh, T. B. Beckinsale, D. B. Saleh, M. Ragbir, C. H. Gerrand, L. Jeys, J. C. Knight, G. Petrides, K. S. Rankin. Advances in Image Enhancement for Sarcoma Surgery. Cancer Lett., 2020, 483, 1-11.
46. James C. Knight, Julia Baguna Torres, Robert Goldin, Michael Mosley, Gemma M. Dias, Luisa Contreras Bravo, Veerle Kersemans, P. Danny Allen, Somnath Mukherjee, Sean Smart, and Bart Cornelissen. Early Detection in a Mouse Model of Pancreatic Cancer by Imaging DNA Damage Response Signalling. J. Nucl. Med., 2020, 61(7), 1006-1013.
45. Cristina Marculescu, Abirami Lakshminarayanan, Joseph Gault, James C. Knight, Lisa K. Folkes, Thomas Spink, Carol V. Robinson, Katherine Vallis, Benjamin G. Davis, and Bart Cornelissen. Probing the Limits of Q-Tag Bioconjugation of Antibodies. Chem. Commun. 2019, 55, 11342-11345.
44. James C. Knight, Michael J. Mosley, Veerle Kersemans, Gemma M. Dias, P. Danny Allen, Sean Smart, and Bart Cornelissen. Dual-Isotope Imaging Allows In Vivo Immunohistochemistry Using Radiolabelled Antibodies in Tumours. Nucl. Med. Biol. 2019, 70, 14-22. (MOST DOWNLOADED ARTICLE)
43. Melinda Wuest, Amanda Perreault, Susan Richter, James C. Knight and Frank Wuest. Targeting Phosphatidylserine for radionuclide-based molecular imaging of apoptosis. Apoptosis. 2019, 24(3-4), 221-244.
42. James C. Knight and Bart Cornelissen. Click Chemistry in Radiochemistry. In: J. Lewis, A. Windhorst, B. Zeglis (eds), Radiopharmaceutical Chemistry. 2019, Springer, 467-479.
41. Thomas Wilson, Mary-Ann Xavier, James C. Knight, Stefan Verhoog, Julia Baguña Torres, Michael Mosley, Samantha Hopkins, Sheena Wallington, Danny Allen, Veerle Kersemans, Rebekka Hueting, Sean Smart, Veronique Gouverneur, Bart Cornelissen. PET Imaging of PARP Expression Using [18F]Olaparib. J. Nucl. Med., 2019, 60(4), 504-510.
40. Bart Cornelissen, James C. Knight, Somnath Mukherjee, Laura Evangelista, Catarina Xavier, Federico Caobelli, Silvana Del Vecchio, Latifa Rbah-Vidal, Jacques Barbet, Marion de Jong, Fijs WB van Leeuwen. Translational Molecular Imaging in Exocrine Pancreatic Cancer. Eur. J. Nucl. Med. Mol. Imaging, 2018, 45(13), 2442-2455.
39. James C. Knight and Bart Cornelissen. Preservation of Ligand Functionality by Click Chemistry. Radionanomedicine, 2018, 251-261, Springer.
38. Julia Baguna Torres, James C. Knight, Michael Mosley, Veerle Kersemans, Sofia Koustoulidou, Danny Allen, Paul Kinchesh, Sean Smart, and Bart Cornelissen*. Imaging of Claudin-4 in pancreastic ductal adenocarcinoma using a radiolabelled anti-Claudin-4 monocloncal antibody; Mol. Imaging Biol., 2018, 20(2), 292-299.
37. James C. Knight, Michael Mosley, Luisa Bravo, Veerle Kersemans, Danny Allen, Somnath Mukherjee, Eric O’Neill, and Bart Cornelissen*. 89Zr-anti-γH2AX-TAT but not 18F-FDG allows early monitoring of response to chemotherapy in a mouse model of pancreatic ductal adenocarcinoma; Clin. Cancer Res., 2017, 23(21), 6498-6504
36. James C. Knight, Michael Mosley, H. Tetsuo Uyeda, Mei Cong, Frank Fan, Stephen Faulknerm Bart Cornelissen*. In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme; Mol. Pharm., 2017, 14(7), 2307-2313
35. James C. Knight, Sofia Koustoulidou, and Bart Cornelissen*. Imaging the DNA Damage Response with PET and SPECT; Eur. J. Nucl. Med. Mol. Imaging, 2017, 44(6), 1065-1078.
34. James C. Knight, Stephen J. Paisey, Adam M. Dabkowski, Anwen S. Williams, Christopher Marshall and Bart Cornelissen*. Scaling-down Antibody Radiolabeling Reactions with Zirconium-89; Dalton Trans., 2016, 45(15), 6343-6347.
33. James C. Knight, Peter G. Edwards, Neha Singh, and Angelo J. Amoroso*. Shaping and enforcing coordination spheres: Probing the ability of tripodal ligands to favour trigonal prismatic geometry; Dalton Trans., 2016, 45(26), 10630-10642.
32. Fawaz A. Saad, James C. Knight, Benson M. Kariuki, Angelo J. Amoroso*. Co-ordination Behaviour of a Novel Tristhiourea Tripodal Ligand; Structural, Spectroscopic and Electrochemical Properties of a Series of Transition Metal Complexes; Dalton Trans., 2016, 45(25), 10280-10288.
31. Sai Kiran Sharma, Kuntal K. Sevak, Sebastien Monette, Sean D. Carlin, James C. Knight, Frank R. Wuest, Brian M. Zeglis, Jason S. Lewis*. Preclinical 89Zr-ImmunoPET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis; J. Nucl. Med., 2016, 57(5), 771-776.
30. Amanda Perreault, James C. Knight, Monica Wang, Jenilee Way, Frank Wuest*. 18F-Labeled Wild-Type Annexin V: Comparison of Random and Site-Selective Labeling Approaches; Amino Acids, 2016, 48(1), 65-74.
29. James C. Knight, Caitriona Topping, Michael Mosley, Veerle Kersemans, Nadia Falzone, Bart Cornelissen*. PET Imaging of DNA Damage using 89Zr-Labelled Anti-γH2AX-TAT Immunoconjugates; Eur. J. Nucl. Med. Mol. Imaging, 2015, 42(11), 1707-1717.
28. Christopher R. T. Hillyar, James C. Knight, Katherine Vallis, Bart Cornelissen*. PET and SPECT Imaging for the Acceleration of Anti-Cancer Drug Development; Curr. Drug Targets, 2015, 16, 582-591.
27. Michael Mosley, James C. Knight, Albrecht Neesse, Patrick Michl, Manuela Iezzi, Veerle Kersemans, Bart Cornelissen*. Claudin-4 SPECT Imaging Allows Detection of Aplastic Lesions in a Mouse Model of Breast Cancer; J. Nucl. Med., 2015, 56, 745-751.
26. James C. Knight, Michael Mosley, Michael R. L. Stratford, H. Tetsuo Uyeda, Hélène A. Benink, Mei Cong, F. Fan, Stephen Faulkner, Bart Cornelissen*. Development of an Enzymatic Pretargeting Strategy for Dual-Modality Imaging; Chem. Commun., 2015, 51, 4055-4058.
25. Bart Cornelissen, Sarah Able, Christiana Kartsonaki, Veerle Kersemans, P. Danny Allen, Manuela Lezzi, Federica Cavallo, Jean-Baptiste Cazier, James C. Knight, Ruth Muschel, Sean Smart, and Katherine Vallis*. Imaging DNA Damage Allows Detection of Preneoplasia in the BALB-neuT Model of Breast Cancer; J. Nucl. Med., 2014, 55, 2026-2031.
24. Cuhananthan W. Sathiyajith,* James C. Knight, Benson M. Kariuki, Peter G. Edwards, and Angelo J. Amoroso*. Crystal Structure of the Moonoprotonated Tripodal Ligand 2,2’-bipyrid-6-yl) Methanol; Open J. Chem., 2014, 1, 15-20.
23. Christian Foerster, James C. Knight, Melinda Wuest, Brendan Rowan, Suzanne E. Lapi, Angelo J. Amoroso, Peter G. Edwards, Frank Wuest*. Synthesis, Complex Stability and Small Animal PET Imaging of a Novel 64Cu-Labelled Cryptand Molecule; Chem. Commun., 2014, 5, 958-962.
22. James C. Knight and Bart Cornelissen*. Bioorthogonal Chemistry: Implications for Pretargeted Nuclear (PET/SPECT) Imaging and Therapy; Am. J. Nucl. Med. Mol. Imaging, 2014, 4, 96-113.
21. Fawaz A. Saad, James C. Knight, Benson M. Kariuki, and Angelo J. Amoroso*. Co-ordinative Properties of a Tripodal Trisamide Ligand with a Capped Octahedral Preference; Dalton Trans., 2013, 42, 14826-14835. (HOT ARTICLE).
20. James C. Knight, Melinda Wuest, Fawaz A. Saad, Monica Wang, David W. Chapman, Hans-Soenke Jans, Suzanne E. Lapi, Benson M. Kariuki, Angelo J. Amoroso,* and Frank Wuest*. Synthesis, Characterisation and Evaluation of a Novel Copper-64 Complex with Selective Uptake in EMT-6 Cells Under Hypoxic Conditions; Dalton Trans., 2013, 42, 12005-12014.
19. James C. Knight, Susan Richter, Melinda Wuest, Jenilee Way, and Frank Wuest*. Synthesis and Evaluation of an 18F-labelled Norbornene Derivative for Copper-free Click Chemistry Reactions; Org. Biomol. Chem., 2013, 11, 3817-3825.
18. James C. Knight,* and Frank R. Wuest. Nuclear (PET/SPECT) and Optical Imaging Probes Targeting the CXCR4 Chemokine Receptor; Chem. Commun., 2012, 3, 1039-1053. Highlighted in the MedChemComm blog.
17. Fawaz A. Saad, Niklaas J. Buurma, Angelo J. Amoroso,* James C. Knight, and Benson M. Kariuki. Coordination Behaviour of a Novel Bisthiourea Tripodal Ligand; Structural, Spectroscopic and Electrochemical Properties of a Series of Transition Metal Complexes; Dalton Trans., 2012, 41, 4608-4617.
16. James C. Knight, Ravi Prabaharan, Angelo J. Amoroso,* Peter G. Edwards,* and Li-ling Ooi. Synthesis and Co-ordination Chemistry of Tris(picolyl-2-carboxyamido-6-pyridyl)methanol: A Ligand with a Strong Preference for Trigonal Prismatic Geometries; Polyhedron, 2012, 31, 457-462.
15. James C. Knight,* Peter G. Edwards, and Stephen J. Paisey. Fluorinated Contrast Agents for Magnetic Resonance Imaging; A Review of Recent Developments; RSC Advances, 2011, 1, 1415-1425. (MOST READ ARTICLE) Highlighted in the RSC Advances blog.
14. James C. Knight, Andrew J. Hallett, Andrea Brancale, Stephen J. Paisey,* Richard W. E. Clarkson,* and Peter G. Edwards*. Evaluation of a Fluorescent Derivative of AMD3100 and its Interaction with the CXCR4 Chemokine Receptor; ChemBioChem, 2011, 12, 2692-2698.
13. Cristina Carcedo, James C. Knight, Simon J. A. Pope, Ian A. Fallis,* and Athanasia Dervisi*. Chiral Silver and Gold Rings: Synthesis and Structural, Spectroscopic, and Photophysical Properties of Ag and Au Metallamacrocycles of Bridging NHC Ligands; Organometallics, 2011, 30, 2553-2562.
12. James C. Knight, Ravi Prabaharan, Peter G. Edwards,* and Angelo J. Amoroso*. Coordination of a New Bis-Terpyridine Ligand with Cupric Perchlorate Yielding a Dinuclear M2L Species; J. Mol. Struct., 2011, 989, 86-90.
11. James C. Knight, Ravi Prabaharan, Benjamin D. Ward, Angelo J. Amoroso,* Peter G. Edwards,* and Benson M. Kariuki. A Facile One-Pot Synthesis of a New Cryptand via a Pd(II)-catalysed Carbonylation Reaction; Dalton Trans., 2010, 39, 10031-10033.
10. James C. Knight, Angelo J. Amoroso,* Peter G. Edwards, Ravi Prabaharan and Neha Singh. The Co-ordination Chemistry of Bis(2,2’-bipyrid-6’-yl)ketone with First Row Transition Metals: The Reversible Interconversion of a Mononuclear Complex and a Dinuclear Hemiketal Containing Species; Dalton Trans., 2010, 39, 8925-8936. (HOT ARTICLE).
9. James C. Knight* and Ian A. Fallis. 1,1’-(Ethane-1,2-diyl)bis(1,4,7-triazone); Acta Crystallogr. Sect. E, 2010, E66, o1513.
8. Peter G. Edwards,* James C. Knight and Paul D. Newman*. Synthesis of (1R,4S,6R)-5,5,6-trimethyl-2-phosphabicyclo[2.2.2]octane and derivatives; Dalton Trans., 2010, 39, 3851-3860.
7. James C. Knight, Angelo J. Amoroso,* Santiago Alvarez, Peter G. Edwards* and Neha Singh. A Novel Bipyridine-based Hexadentate Tripodal Framework with a Strong Preference for Trigonal Prismatic Coordination Geometries; Dalton Trans., 2010, 39, 3870-3883.
6. Angelo J. Amoroso,* Peter G. Edwards, James C. Knight, Sian T. Howard, Lisa Stratford, K. M. Adbul Malik, A.-R. H. Al-Sudani, Li-Ling Ooi and Benson M. Kariuki. The Synthesis and Coordination Chemistry of a Novel Tris-8-aminoquinoline Tripod; Dalton Trans., 2009, 8356-8362.
5. James C. Knight,* Fawaz A. Saad, Angelo J. Amoroso, Benson M. Kariuki and Simon J. Coles. rac-N-{6-[Bromo(hydroxy)methyl]-2-pyridyl}pivalamide; Acta Crystallogr. Sect. E, 2009, 65, o647.
4. Manuel Iglesias, Dirk J. Beestra, James C. Knight, Li-Ling Ooi, Andreas Stasch, Simon J. Coles, Louise Male, Michael B. Hursthouse, Kingsley J. Cavell,* Athanasia Dervisi* and Ian A. Fallis.* Novel Expanded Ring N-heterocyclic Carbenes: Free Carbenes, Silver Complexes and Structures; Organometallics, 2008, 27 (13), 3279-3289.
3. James C. Knight,* Angelo J. Amoroso, Peter G. Edwards and Ravi Prabaharan. Bis{N-[bis(6-bromopyridin-2-yl)methylene-κN]ethane-1,2-diamine-κ2N,N’}nickel(II) bis(perchlorate); Acta Crystallogr. Sect. E, 2007, 63, m1046-m1047.
2. James C. Knight,* Thomas Tatchell and Ian A. Fallis. 2-(Cyclohexylamino)-1,4-naphthoquinone; Acta Crystallogr. Sect. E, 2007, 63, o1226-o1227.
1. James C. Knight,* Angelo J. Amoroso, Peter G. Edwards and Li-Ling Ooi. Catena-Poly[[[diaquacadmium(II)]-μ-2,2’-bipyridine-6,6’-dicarboxylato] dihydrate]; Acta Crystallogr. Sect. E, 2006, 62, m3306–m3308.