Dr. James C Knight

 

I am a lecturer in radiochemistry in the School of Natural and Environmental Sciences at Newcastle University. My research focusses on the synthesis and preclinical evaluation of radiopharmaceuticals for imaging and therapeutic applications.

I am the Degree Programme Director for MSc Drug Chemistry and the lead for radiochemistry within the Discovery of Medicines research theme in the Faculty of Medical Sciences.

I have published >50 papers (with >1000 citations) in this area and have recently co-authored 2 textbooks on click chemistry and its role in radiochemistry. I also sit on the editorial board of several peer-reviewed journals.

My research has been generously supported by EPSRC, Orthopaedic Research UK, UK SPINE, Wellcome Trust, and NIHR.

Latest Publications

54. Toni A. Pringle, Erik-Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight*, Saimir Luli*. Synthesis and Preclinical Evaluation of a 89Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury. Scientific Reports, 2024, 14, 633.

53. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. Synthesis and in vitro evaluation of a HER2-specific immunoSCIFI probe. ACS Omega, 2023, 8, 50, 47905-47912. (journal cover).

52. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. In situ excitation of BODIPY fluorophores by Cerenkov Luminescence. Chem. Commun., 2022, 58, 11689-11692.

Graphical abstract: In situ excitation of BODIPY fluorophores by 89Zr-generated Cerenkov luminescence

51. Toni A. Pringle, Oliver Coleman, Akane Kawamura, James C. Knight*. The Influence of Degree of Labelling upon Cellular Internalisation of Antibody-Cell Penetrating Peptide Conjugates. RSC Advances, 2022, 12, 27716-27722.

50. Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen Blair, Kenneth S. Rankin*, James C. Knight*. Synthesis and In Vivo Evaluation of a Site-Specifically Labelled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Bioconjugate Chemistry, 2022, 33(8), 1564-1573. (journal cover).

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