Dr. James C Knight
I am a lecturer in radiochemistry in the School of Natural and Environmental Sciences at Newcastle University. My research focusses on the synthesis and preclinical evaluation of radiopharmaceuticals for imaging and therapeutic applications.
I am the Head of Admissions for MSc Chemistry and Drug Chemistry programmes and the lead for radiochemistry within the Discovery of Medicines research theme in the Faculty of Medical Sciences. I was previously the Degree Programme Director for MSc Drug Chemistry.
I have published >50 papers (with >1000 citations) in this area and have recently co-authored 2 textbooks on click chemistry and its role in radiochemistry. I also sit on the editorial board of several peer-reviewed journals.
My research has been generously supported by EPSRC, Orthopaedic Research UK, UK SPINE, Wellcome Trust, and NIHR.
Latest Publications
57. Stavros Melemenidis, James C. Knight, Veerle Kersemans, Francisco Perez-Balderas, Niloufar Zarghami, Manuel Sarmiento Soto, Bart Cornelissen, Ruth J. Muschel, and Nicola R. Sibson*. 2024. In Vivo PET Detection of Lung Micrometastasis in Mice by Targeting Endothelial VCAM-1 Using a Dual-Contrast PET/MRI Probe. International Journal of Molecular Sciences, 2024, 25(13), 7160, 1-19.
56. Tracey Luu, Katie Gristwood, James C. Knight*, and Manuela Jörg*. Click Chemistry: Reaction Rates and Their Suitability for Biomedical Applications. Bioconjugate Chemistry, 2024, in press, doi.org/10.1021/acs.bioconjchem.4c00084
55. Lydia Cooke, Katie Gristwood, Kate Adamson, Mark Sims, Michael Deary, Dawn Bruce, Antony Antoniou, Hannah Walden, James C. Knight, Timothé Antoine-Brunet, Marie Joly, David Goyard, Pierre-Henri Lanoë, Nathalie Berthet, Valery Kozhevnikov*. Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Strain Alkynes. BioRxiv, 2024, Preprint at doi:10.26434/chemrxiv-2024-r4p1p
54. Toni A. Pringle, Erik-Ramon-Gil, Jack Leslie, Fiona Oakley, Matthew C. Wright, James C. Knight*, Saimir Luli*. Synthesis and Preclinical Evaluation of a 89Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury. Scientific Reports, 2024, 14, 633.
53. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. Synthesis and in vitro evaluation of a HER2-specific immunoSCIFI probe. ACS Omega, 2023, 8, 50, 47905-47912. (journal cover).
52. Katie Gristwood, Saimir Luli, Kenneth S. Rankin, James C. Knight*. In situ excitation of BODIPY fluorophores by Cerenkov Luminescence. Chem. Commun., 2022, 58, 11689-11692.
51. Toni A. Pringle, Oliver Coleman, Akane Kawamura, James C. Knight*. The Influence of Degree of Labelling upon Cellular Internalisation of Antibody-Cell Penetrating Peptide Conjugates. RSC Advances, 2022, 12, 27716-27722.
50. Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen Blair, Kenneth S. Rankin*, James C. Knight*. Synthesis and In Vivo Evaluation of a Site-Specifically Labelled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. Bioconjugate Chemistry, 2022, 33(8), 1564-1573. (journal cover).
